Estimating the Exposure–Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project

Estimating the Exposure–Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project

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Estimating the Exposure–Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project

dc.contributor.author	Samoli, Evangelia
dc.contributor.author	Analitis, Antonis
dc.contributor.author	Touloumi, Giota
dc.contributor.author	Anderson, Hugh R.
dc.contributor.author	Sunyer, Jordi
dc.contributor.author	Bisanti, Luigi
dc.contributor.author	Zmirou, Denis
dc.contributor.author	Vonk, Judith M.
dc.contributor.author	Pekkanen, Juha
dc.contributor.author	Paldy, Anna
dc.contributor.author	Schindler, Christian
dc.contributor.author	Katsouyanni, Klea
dc.contributor.author	Schwartz, Joel David
dc.contributor.author	Goodman, Pat
dc.date.accessioned	2011-04-22T19:53:46Z
dc.date.issued	2004
dc.identifier.citation	Samoli, Evangelia, Antonis Analitis, Giota Touloumi, Joel Schwartz, Hugh R. Anderson, Jordi Sunyer, Luigi Bisanti, et al. 2005. Estimating the Exposureâ Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project. Environmental Health Perspectives 113(1): 88-95.	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874506
dc.description.abstract	Several studies have reported significant health effects of air pollution even at low levels of air pollutants, but in most of theses studies linear nonthreshold relations were assumed. We investigated the exposure–response association between ambient particles and mortality in the 22 European cities participating in the APHEA (Air Pollution and Health—A European Approach) project, which is the largest available European database. We estimated the exposure–response curves using regression spline models with two knots and then combined the individual city estimates of the spline to get an overall exposure–response relationship. To further explore the heterogeneity in the observed city-specific exposure–response associations, we investigated several city descriptive variables as potential effect modifiers that could alter the shape of the curve. We conclude that the association between ambient particles and mortality in the cities included in the present analysis, and in the range of the pollutant common in all analyzed cities, could be adequately estimated using the linear model. Our results confirm those previously reported in Europe and the United States. The heterogeneity found in the different city-specific relations reflects real effect modification, which can be explained partly by factors characterizing the air pollution mix, climate, and the health of the population.	en_US
dc.language.iso	en_US	en_US
dc.publisher	National Institue of Environmental Health Sciences	en_US
dc.relation.isversionof	doi:10.1289/ehp.7387	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253715/pdf/	en_US
dash.license	LAA
dc.subject	air pollution	en_US
dc.subject	exposure–response	en_US
dc.subject	heterogeneity	en_US
dc.subject	hierarchical modeling	en_US
dc.subject	mortality	en_US
dc.subject	splines	en_US
dc.title	Estimating the Exposure–Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Environmental Health Perspectives	en_US
dash.depositing.author	Schwartz, Joel David
dc.date.available	2011-04-22T19:53:46Z
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	SPH^Exposure Epidemiology and Risk Program	en_US