Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study
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Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study
| Title: | Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study |
| Author: |
Byrne, Celia; Rosner, Bernie; Tamimi, Rulla May; Baer, Heather Joanne; Schnitt, Stuart Jay; Connolly, James Leo; Colditz, Graham A.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Tamimi, Rulla M, Celia Byrne, Heather J Baer, Bernie Rosner, Stuart J Schnitt, James L Connolly, and Graham A Colditz. 2005. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case- control study. Breast Cancer Research 7(4): R555-R562. |
| Full Text & Related Files: |
1175067.pdf (183.4Kb; PDF) 
|
| Abstract: | Introduction: Alcohol consumption is a well-established risk factor for breast cancer. Some studies have suggested that the risk of breast cancer associated with alcohol consumption is greater for women with a history of benign breast disease (BBD). We hypothesized that among women with biopsy-confirmed BBD, recent alcohol consumption would increase the risk of breast cancer in women with proliferative breast disease to a greater extent than in women with nonproliferative breast disease. Methods: We conducted a nested case–control study in the Nurses' Health Study I and II. The cases (n = 282) were women diagnosed with incident breast cancer, with a prior biopsy-confirmed breast disease. The controls (n = 1,223) were participants with a previous BBD biopsy, but without a diagnosis of breast cancer. Pathologists reviewed benign breast biopsy slides in a blinded fashion and classified the BBD as nonproliferative, proliferative without atypia, or atypical hyperplasia, according to standard criteria. Results: Women with nonproliferative breast disease consuming ≥ 15 g of alcohol per day had a nonsignificant 67% increased risk of breast cancer (odds ratio = 1.67; 95% confidence interval 0.65 to 4.34) compared with nondrinkers. There was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent in women with proliferative BBD than among women with nonproliferative BBD (P for interactio n = 0.20). Conclusion: Contrary to our a priori hypothesis, there was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent among women with proliferative BBD than among women with nonproliferative BBD. |
| Published Version: | doi://10.1186/bcr1039 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175067/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874589 |
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