Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

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Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

dc.contributor.author	Byrne, Celia
dc.contributor.author	Rosner, Bernie
dc.contributor.author	Tamimi, Rulla May
dc.contributor.author	Baer, Heather Joanne
dc.contributor.author	Schnitt, Stuart Jay
dc.contributor.author	Connolly, James Leo
dc.contributor.author	Colditz, Graham A.
dc.date.accessioned	2011-04-22T21:11:33Z
dc.date.issued	2005
dc.identifier.citation	Tamimi, Rulla M, Celia Byrne, Heather J Baer, Bernie Rosner, Stuart J Schnitt, James L Connolly, and Graham A Colditz. 2005. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case- control study. Breast Cancer Research 7(4): R555-R562.	en_US
dc.identifier.issn	1465-5411	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874589
dc.description.abstract	Introduction: Alcohol consumption is a well-established risk factor for breast cancer. Some studies have suggested that the risk of breast cancer associated with alcohol consumption is greater for women with a history of benign breast disease (BBD). We hypothesized that among women with biopsy-confirmed BBD, recent alcohol consumption would increase the risk of breast cancer in women with proliferative breast disease to a greater extent than in women with nonproliferative breast disease. Methods: We conducted a nested case–control study in the Nurses' Health Study I and II. The cases (n = 282) were women diagnosed with incident breast cancer, with a prior biopsy-confirmed breast disease. The controls (n = 1,223) were participants with a previous BBD biopsy, but without a diagnosis of breast cancer. Pathologists reviewed benign breast biopsy slides in a blinded fashion and classified the BBD as nonproliferative, proliferative without atypia, or atypical hyperplasia, according to standard criteria. Results: Women with nonproliferative breast disease consuming ≥ 15 g of alcohol per day had a nonsignificant 67% increased risk of breast cancer (odds ratio = 1.67; 95% confidence interval 0.65 to 4.34) compared with nondrinkers. There was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent in women with proliferative BBD than among women with nonproliferative BBD (P for interactio n = 0.20). Conclusion: Contrary to our a priori hypothesis, there was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent among women with proliferative BBD than among women with nonproliferative BBD.	en_US
dc.language.iso	en_US	en_US
dc.publisher	BioMed Central	en_US
dc.relation.isversionof	doi://10.1186/bcr1039	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175067/pdf/	en_US
dash.license	LAA
dc.title	Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Breast Cancer Research	en_US
dash.depositing.author	Tamimi, Rulla May
dc.date.available	2011-04-22T21:11:33Z
dash.affiliation.other	SPH^Epidemiology	en_US
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	SPH^Epidemiology	en_US
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	SPH^Epidemiology	en_US