Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

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Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

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dc.contributor.author Byrne, Celia
dc.contributor.author Rosner, Bernie
dc.contributor.author Tamimi, Rulla May
dc.contributor.author Baer, Heather Joanne
dc.contributor.author Schnitt, Stuart Jay
dc.contributor.author Connolly, James Leo
dc.contributor.author Colditz, Graham A.
dc.date.accessioned 2011-04-22T21:11:33Z
dc.date.issued 2005
dc.identifier.citation Tamimi, Rulla M, Celia Byrne, Heather J Baer, Bernie Rosner, Stuart J Schnitt, James L Connolly, and Graham A Colditz. 2005. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case- control study. Breast Cancer Research 7(4): R555-R562. en_US
dc.identifier.issn 1465-5411 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874589
dc.description.abstract Introduction: Alcohol consumption is a well-established risk factor for breast cancer. Some studies have suggested that the risk of breast cancer associated with alcohol consumption is greater for women with a history of benign breast disease (BBD). We hypothesized that among women with biopsy-confirmed BBD, recent alcohol consumption would increase the risk of breast cancer in women with proliferative breast disease to a greater extent than in women with nonproliferative breast disease. Methods: We conducted a nested case–control study in the Nurses' Health Study I and II. The cases (n = 282) were women diagnosed with incident breast cancer, with a prior biopsy-confirmed breast disease. The controls (n = 1,223) were participants with a previous BBD biopsy, but without a diagnosis of breast cancer. Pathologists reviewed benign breast biopsy slides in a blinded fashion and classified the BBD as nonproliferative, proliferative without atypia, or atypical hyperplasia, according to standard criteria. Results: Women with nonproliferative breast disease consuming ≥ 15 g of alcohol per day had a nonsignificant 67% increased risk of breast cancer (odds ratio = 1.67; 95% confidence interval 0.65 to 4.34) compared with nondrinkers. There was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent in women with proliferative BBD than among women with nonproliferative BBD (P for interactio n = 0.20). Conclusion: Contrary to our a priori hypothesis, there was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent among women with proliferative BBD than among women with nonproliferative BBD. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/bcr1039 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175067/pdf/ en_US
dash.license LAA
dc.title Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Breast Cancer Research en_US
dash.depositing.author Tamimi, Rulla May
dc.date.available 2011-04-22T21:11:33Z
dash.affiliation.other SPH^Epidemiology en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Epidemiology en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other SPH^Epidemiology en_US

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