Within-home versus between-home variability of house dust endotoxin in a birth cohort

Within-home versus between-home variability of house dust endotoxin in a birth cohort

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Within-home versus between-home variability of house dust endotoxin in a birth cohort

dc.contributor.author	Abraham, Joseph H.
dc.contributor.author	Park, Ju-Hyeong
dc.contributor.author	Gold, Diane R.
dc.contributor.author	Ryan, Louise Marie
dc.contributor.author	Milton, Donald Kirby
dc.contributor.author	Dockery, Douglas W.
dc.date.accessioned	2011-04-22T21:22:17Z
dc.date.issued	2005
dc.identifier.citation	Abraham, Joseph H., Diane R. Gold, Douglas W. Dockery, Louise Ryan, Ju-Hyeong Park, and Donald K. Milton. 2005. Within-home versus between-home variability of house dust endotoxin in a birth cohort. Environmental Health Perspectives 113(11): 1516-1521.	en_US
dc.identifier.issn	0091-6765	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874654
dc.description.abstract	Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5–11 months. We analyzed 1,287 dust samples from the kitchen, family room, and baby’s bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time.	en_US
dc.language.iso	en_US	en_US
dc.publisher	National Institute of Environmental Health Sciences	en_US
dc.relation.isversionof	doi:10.1289/ehp.7632	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310912/pdf/	en_US
dash.license	LAA
dc.subject	dust endotoxin	en_US
dc.subject	endotoxin	en_US
dc.subject	intraclass correlation	en_US
dc.subject	variance components	en_US
dc.title	Within-home versus between-home variability of house dust endotoxin in a birth cohort	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Environmental Health Perspectives	en_US
dash.depositing.author	Gold, Diane R.
dc.date.available	2011-04-22T21:22:17Z
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	SPH^Exposure Epidemiology and Risk Program	en_US
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	SPH^Exposure Epidemiology and Risk Program	en_US
dash.affiliation.other	SPH^Environmental Health	en_US
dash.affiliation.other	SPH^Biostatistics	en_US
dash.affiliation.other	SPH^Exposure Epidemiology and Risk Program	en_US