Within-home versus between-home variability of house dust endotoxin in a birth cohort

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Within-home versus between-home variability of house dust endotoxin in a birth cohort

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dc.contributor.author Abraham, Joseph H.
dc.contributor.author Park, Ju-Hyeong
dc.contributor.author Gold, Diane R.
dc.contributor.author Ryan, Louise Marie
dc.contributor.author Milton, Donald Kirby
dc.contributor.author Dockery, Douglas W.
dc.date.accessioned 2011-04-22T21:22:17Z
dc.date.issued 2005
dc.identifier.citation Abraham, Joseph H., Diane R. Gold, Douglas W. Dockery, Louise Ryan, Ju-Hyeong Park, and Donald K. Milton. 2005. Within-home versus between-home variability of house dust endotoxin in a birth cohort. Environmental Health Perspectives 113(11): 1516-1521. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874654
dc.description.abstract Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5–11 months. We analyzed 1,287 dust samples from the kitchen, family room, and baby’s bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.7632 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310912/pdf/ en_US
dash.license LAA
dc.subject dust endotoxin en_US
dc.subject endotoxin en_US
dc.subject intraclass correlation en_US
dc.subject variance components en_US
dc.title Within-home versus between-home variability of house dust endotoxin in a birth cohort en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Gold, Diane R.
dc.date.available 2011-04-22T21:22:17Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other SPH^Environmental Health en_US
dash.affiliation.other SPH^Biostatistics en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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