Effect of breast milk lead on infant blood lead levels at 1 month of age

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Effect of breast milk lead on infant blood lead levels at 1 month of age

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dc.contributor.author Téllez-Rojo, Martha María
dc.contributor.author Hu, Howard
dc.contributor.author Hernández-Avila, Mauricio
dc.contributor.author Ettinger, Adrienne S
dc.contributor.author Amarasiriwardena, Chitra J.
dc.contributor.author Bellinger, David C.
dc.contributor.author Peterson, Karen E.
dc.contributor.author Schwartz, Joel David
dc.date.accessioned 2011-04-23T00:21:11Z
dc.date.issued 2004
dc.identifier.citation Ettinger, Adrienne S., Martha Marí­a Téllez-Rojo, Chitra Amarasiriwardena, David Bellinger, Karen Peterson, Joel Schwartz, Howard Hu, and Mauricio Hernández-Avila. 2004. Effect of breast milk lead on infant blood lead levels at 1 month of age. Environmental Health Perspectives 112(14): 1381-1385. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874755
dc.description.abstract Nursing infants may be exposed to lead from breast milk, but relatively few data exist with which to evaluate and quantify this relationship. This route of exposure constitutes a potential infant hazard from mothers with current ongoing exposure to lead as well as from mothers who have been exposed previously due to the redistribution of cumulative maternal bone lead stores. We studied the relationship between maternal breast milk lead and infant blood lead levels among 255 mother–infant pairs exclusively or partially breast-feeding through 1 month of age in Mexico City. A rigorous, well-validated technique was used to collect, prepare, and analyze the samples of breast milk to minimize the potential for environmental contamination and maximize the percent recovery of lead. Umbilical cord and maternal blood lead were measured at delivery; 1 month after delivery (± 5 days) maternal blood, bone, and breast milk and infant blood lead levels were obtained. Levels of lead at 1 month postpartum were, for breast milk, 0.3–8.0 μg/L (mean ± SD, 1.5 ± 1.2); maternal blood lead, 2.9–29.9 μg/dL (mean ± SD, 9.4 ± 4.5); and infant blood lead, 1.0–23.1 μg/dL (mean ± SD, 5.5 ± 3.0). Infant blood lead at 1 month postpartum was significantly correlated with umbilical cord (Spearman correlation coefficient rS = 0.40, p < 0.0001) and maternal (rS = 0.42, p < 0.0001) blood lead at delivery and with maternal blood (rS = 0.67, p < 0.0001), patella (rS = 0.19, p = 0.004), and breast milk (rS = 0.32, p < 0.0001) lead at 1 month postpartum. Adjusting for cord blood lead, infant weight change, and reported breast-feeding status, a difference of approximately 2 μg/L (ppb; from the midpoint of the lowest quartile to the midpoint of the highest quartile) breast milk lead was associated with a 0.82 μg/dL increase in blood lead for breast-feeding infants at 1 month of age. Breast milk lead accounted for 12% of the variance of infant blood lead levels, whereas maternal blood lead accounted for 30%. Although these levels of lead in breast milk were low, they clearly have a strong influence on infant blood lead levels over and above the influence of maternal blood lead. Additional information on the lead content of dietary alternatives and interactions with other nutritional factors should be considered. However, because human milk is the best and most complete nutritional source for young infants, breast-feeding should be encouraged because the absolute values of the effects are small within this range of lead concentrations. en_US
dc.language.iso en_US en_US
dc.publisher National Institue of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.6616 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247564/pdf/ en_US
dash.license LAA
dc.subject blood lead en_US
dc.subject breast milk lead en_US
dc.subject breast-feeding en_US
dc.subject KXRF bone lead en_US
dc.subject lactation en_US
dc.title Effect of breast milk lead on infant blood lead levels at 1 month of age en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Ettinger, Adrienne S
dc.date.available 2011-04-23T00:21:11Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Neurology-Children's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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