dc.contributor.author | Cavallari, Jennifer Margaret | |
dc.contributor.author | Eisen, Ellen A. | |
dc.contributor.author | Chen, Jiu-Chiuan | |
dc.contributor.author | Fang, Shona C. | |
dc.contributor.author | Dobson, Christine | |
dc.contributor.author | Schwartz, Joel David | |
dc.contributor.author | Christiani, David C. | |
dc.date.accessioned | 2011-04-23T00:31:41Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Cavallari, Jennifer M., Ellen A. Eisen, Jiu-Chiuan Chen, Shona C. Fang, Christine B. Dobson, Joel Schwartz, and David C. Christiani. 2007. Night heart rate variability and particulate exposures among boilermaker construction workers. Environmental Health Perspectives 115(7): 1046-1051. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874759 | |
dc.description.abstract | Background: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate exposures remains unclear. Objective: Our goal in this study was to investigate the association between long-duration HRV, including nighttime HRV, and occupational PM2.5 exposures. Methods: We used 24-hr ambulatory electrocardiograms (ECGs) to monitor 36 male boilermaker welders (mean age of 41 years) over a workday and nonworkday. ECGs were analyzed for HRV in the time domain; rMSSD (square root of the mean squared differences of successive intervals), SDNN (SD of normal-to-normal intervals over entire recording), and SDNNi (SDNN for all 5-min segments) were summarized over 24-hr, day (0730–2130 hours), and night (0000–0700 hours) periods. PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm) exposures were monitored over the workday, and 8-hr time-weighted average concentrations were calculated. We used linear regression to assess the associations between HRV and workday particulate exposures. Matched measurements from a nonworkday were used to control for individual cardiac risk factors. Results: Mean (± SD) PM2.5 exposure was 0.73 ± 0.50 mg/m3 and ranged from 0.04 to 2.70 mg/m3. We observed a consistent inverse exposure–response relationship, with a decrease in all HRV measures with increased PM2.5 exposure. However, the decrease was most pronounced at night, where a 1-mg/m3 increase in PM2.5 was associated with a change of −8.32 [95% confidence interval (CI), −16.29 to −0.35] msec nighttime rMSSD, −14.77 (95% CI, −31.52 to 1.97) msec nighttime SDNN, and −8.37 (95% CI, −17.93 to 1.20) msec nighttime SDNNi, after adjusting for nonworking nighttime HRV, age, and smoking. Conclusion: Metal-rich particulate exposures were associated with decreased long-duration HRV, especially at night. Further research is needed to elucidate which particulate metal constituent is responsible for decreased HRV. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi:10.1289/ehp.10019 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913585/pdf/ | en_US |
dash.license | LAA | |
dc.subject | environmental cardiology | en_US |
dc.subject | heart rate variability | en_US |
dc.subject | occupational | en_US |
dc.subject | particulate exposures | en_US |
dc.subject | welders | en_US |
dc.title | Night heart rate variability and particulate exposures among boilermaker construction workers | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Cavallari, Jennifer Margaret | |
dc.date.available | 2011-04-23T00:31:41Z | |
dash.affiliation.other | SPH^Environmental+Occupational Medicine+Epi | en_US |
dash.affiliation.other | SPH^Environmental+Occupational Medicine+Epi | en_US |
dash.affiliation.other | SPH^Student Stipends^EH | en_US |
dash.affiliation.other | SPH^Student Stipends | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Exposure Epidemiology and Risk Program | en_US |
dash.affiliation.other | HMS^Medicine-Massachusetts General Hospital | en_US |
dash.affiliation.other | SPH^Environmental+Occupational Medicine+Epi | en_US |
dc.identifier.doi | 10.1289/ehp.10019 | * |
dash.contributor.affiliated | Dobson, Christine | |
dash.contributor.affiliated | Fang, Shona C | |
dash.contributor.affiliated | Cavallari, Jennifer M | |
dash.contributor.affiliated | Christiani, David | |
dash.contributor.affiliated | Eisen, Ellen | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |