Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model

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Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model

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Title: Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model
Author: Zhao, Jin-Lu; Zhang, Chun-Peng; Lin, Luo-Qiang; Chen, Hong-Sheng; Zhang, Shu-Jun; Jin, Jun-Chao; Li, Le-Jing; Liu, Yan; Liu, Ming; Li, Bin; Wang, Lei; Liu, Jia-Ren

Note: Order does not necessarily reflect citation order of authors.

Citation: Liu, Yan, Ming Liu, Bin Li, Jin-Lu Zhao, Chun-Peng Zhang, Luo-Qiang Lin, Hong-Sheng Chen, et al. 2010. Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model. Nutrition & Metabolism 7: 84.
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Abstract: Background: Red raspberry possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro. Methods: The objective of this study was to determine the protective effects of raspberry 80% acetone extract in a rat hepatic lesions model induced by diethylnitrosamine (DEN). Rats were treated with the red raspberry extract (0.75, 1.5 or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continuing for 20 weeks. Results: A dose-dependent inhibition by red raspberry extract of DEN-induced hepatic nodule formation which stands for hepatic lesions was observed. Corresponding hepatic nodule incidence rates were 45.0, 40.0, 25.0 and 5.0% in positive control, low, middle and high groups, respectively (P < 0.01 or 0.05). Gross findings, histopathological and ultrastructural evaluations of hepatic lesion were performed on 9, 8, 5 and 1 hepatic nodule in positive control, low, middle and high doses of groups, respectively, identified in rats from the respective groups of 20. A decreasing trend of proportions of hepatocellular carcinoma masses accompanied the increasing doses of red raspberry extract. Conclusions: These findings demonstrate that the potent capacity of red raspberry diet could not only suppress DEN-induced hepatic lesions in rats, but also reduce the definite diagnostic features of neoplasm.
Published Version: doi:10.1186/1743-7075-7-84
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999596/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874771

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