A unique B2 B cell subset in the intestine

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A unique B2 B cell subset in the intestine

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Title: A unique B2 B cell subset in the intestine
Author: Shimomura, Yasuyo; Ogawa, Atsuhiro; Kawada, Mayumi; Sugimoto, Ken; Shi, Hai-Ning; Pillai, Shiv Subramaniam; Bhan, Atul Kumar; Mizoguchi, Atsushi

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Citation: Shimomura, Yasuyo, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai-Ning Shi, Shiv Pillai, Atul K. Bhan, and Atsushi Mizoguchi. 2008. A unique B2 B cell subset in the intestine. The Journal of Experimental Medicine 205(6): 1343-1355.
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Abstract: Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM[super]+ B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a previously unidentified and unique subset of immunoglobulin M[super]+ B cells that present with an AA4.1[super]−CD21[super]−CD23[super]− major histocompatibility complex class II[super]bright surface phenotype and are characterized by a low frequency of somatic hypermutation and the potential ability to produce interleukin-12p70. This B cell subset resides within the normal mucosa of the large intestine and expands in response to inflammation. Some of these intestinal B cells originate from the AA4.1[super]+ immature B2 cell pool in the steady state and are also recruited from the recirculating naive B cell pool in the context of intestinal inflammation. They develop in an antigen-independent and BAFF-dependent manner in the absence of T cell help. Expansion of these cells can be induced in the absence of the spleen and gut-associated lymphoid tissues. These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset.
Published Version: doi:10.1084/jem.20071572
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413032/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874782

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