Neonatal Fc Receptor: From Immunity to Therapeutics

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Neonatal Fc Receptor: From Immunity to Therapeutics

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dc.contributor.author Yoshida, Masaru
dc.contributor.author Qiao, Shuo-Wang
dc.contributor.author Aveson, Victoria G.
dc.contributor.author Kuo, Timothy Ting-Chang
dc.contributor.author Baker, Kristi Dorothy
dc.contributor.author Lencer, Wayne Isaac
dc.contributor.author Blumberg, Richard Steven
dc.date.accessioned 2011-04-23T14:48:57Z
dc.date.issued 2010
dc.identifier.citation Kuo, Timothy T., Kristi Baker, Masaru Yoshida, Shuo-Wang Qiao, Victoria G. Aveson, Wayne I. Lencer, and Richard S. Blumberg. 2010. Neonatal Fc receptor: from immunity to therapeutics. Journal of Clinical Immunology 30(6): 777-789. en_US
dc.identifier.issn 0271-9142 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874790
dc.description.abstract The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in the transport of IgG from mother to fetus and neonate for passive immunity and later in the development of adaptive immunity and other functions throughout life. The unique ability of this receptor to prolong the half-life of IgG and albumin has guided engineering of novel therapeutics. Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn. en_US
dc.language.iso en_US en_US
dc.publisher Springer US en_US
dc.relation.isversionof doi:10.1007/s10875-010-9468-4 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970823/pdf/ en_US
dash.license LAA
dc.subject FcRn en_US
dc.subject Fcgrt en_US
dc.subject Brambell en_US
dc.subject IgG en_US
dc.subject Fc en_US
dc.subject albumin en_US
dc.subject transcytosis en_US
dc.subject transport en_US
dc.subject recycling en_US
dc.title Neonatal Fc Receptor: From Immunity to Therapeutics en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Clinical Immunology en_US
dash.depositing.author Kuo, Timothy Ting-Chang
dc.date.available 2011-04-23T14:48:57Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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