Neonatal Fc Receptor: From Immunity to Therapeutics

Neonatal Fc Receptor: From Immunity to Therapeutics

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Neonatal Fc Receptor: From Immunity to Therapeutics

dc.contributor.author	Yoshida, Masaru
dc.contributor.author	Qiao, Shuo-Wang
dc.contributor.author	Aveson, Victoria G.
dc.contributor.author	Kuo, Timothy Ting-Chang
dc.contributor.author	Baker, Kristi Dorothy
dc.contributor.author	Lencer, Wayne Isaac
dc.contributor.author	Blumberg, Richard Steven
dc.date.accessioned	2011-04-23T14:48:57Z
dc.date.issued	2010
dc.identifier.citation	Kuo, Timothy T., Kristi Baker, Masaru Yoshida, Shuo-Wang Qiao, Victoria G. Aveson, Wayne I. Lencer, and Richard S. Blumberg. 2010. Neonatal Fc receptor: from immunity to therapeutics. Journal of Clinical Immunology 30(6): 777-789.	en_US
dc.identifier.issn	0271-9142	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874790
dc.description.abstract	The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in the transport of IgG from mother to fetus and neonate for passive immunity and later in the development of adaptive immunity and other functions throughout life. The unique ability of this receptor to prolong the half-life of IgG and albumin has guided engineering of novel therapeutics. Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Springer US	en_US
dc.relation.isversionof	doi:10.1007/s10875-010-9468-4	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970823/pdf/	en_US
dash.license	LAA
dc.subject	FcRn	en_US
dc.subject	Fcgrt	en_US
dc.subject	Brambell	en_US
dc.subject	IgG	en_US
dc.subject	Fc	en_US
dc.subject	albumin	en_US
dc.subject	transcytosis	en_US
dc.subject	transport	en_US
dc.subject	recycling	en_US
dc.title	Neonatal Fc Receptor: From Immunity to Therapeutics	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Journal of Clinical Immunology	en_US
dash.depositing.author	Kuo, Timothy Ting-Chang
dc.date.available	2011-04-23T14:48:57Z
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Pediatrics-Children's Hospital	en_US