Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation

DSpace/Manakin Repository

Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation

Citable link to this page

. . . . . .

Title: Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation
Author: Yang, Ying-Hua; Rajaiah, Rajesh; Fong, Harry H. S.; Lao, Lixing; Berman, Brian M.; Moudgil, Kamal D.; Lee, David Y.-W; Ma, Zhongze; Yu, Hua-Yin

Note: Order does not necessarily reflect citation order of authors.

Citation: Yang, Ying-Hua, Rajesh Rajaiah, David Y.-W Lee, Zhongze Ma, Hua Yu, Harry H. S. Fong, Lixing Lao, Brian M. Berman, and Kamal D. Moudgil. 2011. Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation. Evidence Based Complementary and Alternative Medicine 2011: 642027.
Full Text & Related Files:
Abstract: Rheumatoid arthritis (RA) is one of the major autoimmune diseases of global prevalence. The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity. This limitation has necessitated the search for novel therapeutic products. We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model. HLXL (2.3 g/Kg) was fed to Lewis (RT.1[super]1) rats daily by gavage beginning at the onset of arthritis and then continued through the observation period. HLXL inhibited the severity of ongoing AA. This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65). There was a reduction in the level of the proinflammatory cytokines IL-17 and IL-1β but enhancement of the anti-inflammatory cytokine IL-10 level. In addition, there was inhibition of both the anti-Bhsp65 antibody response and the serum level of nitric oxide. Thus, HLXL is a promising CAM modality for further testing in RA patients.
Published Version: doi:10.1155/2011/642027
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958519/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874817

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters