Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children

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Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children

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dc.contributor.author Mick, Eric Owen
dc.contributor.author Wozniak, Janet Rose
dc.contributor.author Wilens, Timothy Edwin
dc.contributor.author Biederman, Joseph
dc.contributor.author Faraone, Stephen V.
dc.date.accessioned 2011-04-23T17:49:56Z
dc.date.issued 2009
dc.identifier.citation Mick, Eric, Janet Wozniak, Timothy E. Wilens, Joseph Biederman, and Stephen V. Faraone. 2009. Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children. BMC Psychiatry 9: 2. en_US
dc.identifier.issn 1471-244X en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874818
dc.description.abstract Background: Over the past decade pediatric bipolar disorder has gained recognition as a potentially more severe and heritable form of the disorder. In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT). Methods: Bipolar-I affected offspring triads (N = 173) were drawn from 522 individuals with 2 parents in 332 nuclear families recruited for genetic studies of pediatric psychopathology at the Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital. Results: We failed to identify an association with the val66 allele in BDNF (OR = 1.23, p = 0.36), the COMT-l allele (OR = 1.27, p = 0.1), or the HTTLPR short allele (OR = 0.87, p = 0.38). Conclusion: Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1471-244X-9-2 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640390/pdf/ en_US
dash.license LAA
dc.title Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Psychiatry en_US
dash.depositing.author Mick, Eric Owen
dc.date.available 2011-04-23T17:49:56Z
dash.affiliation.other HMS^Psychiatry-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Psychiatry-Massachusetts General Hospital en_US

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