The Twin Questions of Personalized Medicine: Who Are You and Whom Do You Most Resemble?

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The Twin Questions of Personalized Medicine: Who Are You and Whom Do You Most Resemble?

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Title: The Twin Questions of Personalized Medicine: Who Are You and Whom Do You Most Resemble?
Author: Kohane, Isaac Samuel
Citation: Kohane, Isaac S. 2009. The twin questions of personalized medicine: who are you and whom do you most resemble? Genome Medicine 1(1): 4.
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Abstract: Personalized medicine is typically described as the use of molecular or genetic characteristics to customize therapy. This perspective at best provides an incomplete model of the patient and at worst can lead to grossly inappropriate practices. Personalization of medicine requires two characterizations: a well-grounded understanding of who the patient is and an equally robust understanding of the subpopulation that most resembles that patient in the context of the decisions at hand. These characterizations are readily represented probabilistically and can be used to drive decision-making in a rational manner that maximizes the positive outcomes for the patient.
Published Version: doi:10.1186/gm4
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651581/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874842

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