Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

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Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

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dc.contributor.author Chenine, Agnès-Laurence
dc.contributor.author Shai-Kobiler, Ela
dc.contributor.author Steele, Lisa N.
dc.contributor.author Ong, Helena
dc.contributor.author Augostini, Peter
dc.contributor.author Song, Ruijiang
dc.contributor.author Autissier, Patrick
dc.contributor.author Secor, W. Evan
dc.contributor.author Lee, Sandra J.
dc.contributor.author Ruprecht, Ruth Margrit
dc.date.accessioned 2011-04-25T14:21:22Z
dc.date.issued 2008
dc.identifier.citation Chenine, Agnès-Laurence, Ela Shai-Kobiler, Lisa N. Steele, Helena Ong, Peter Augostini, Ruijiang Song, Sandra J. Lee, Patrick Autissier, Ruth M. Ruprecht, and W. Evan Secor. 2008. Acute Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure. PLoS Neglected Tropical Diseases 2(7). en_US
dc.identifier.issn 1935-2727 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4875086
dc.description.abstract Background: Individuals living in sub-Saharan Africa represent 10% of the world's population but almost 2/3 of all HIV-1/AIDS cases. The disproportionate HIV-1 infection rates in this region may be linked to helminthic parasite infections that affect many individuals in the developing world. However, the hypothesis that parasite infection increases an individual's susceptibility to HIV-1 has never been prospectively tested in a relevant in vivo model. Methodology/Principal Findings: We measured whether pre-existing infection of rhesus monkeys with a parasitic worm would facilitate systemic infection after mucosal AIDS virus exposure. Two groups of animals, one consisting of normal monkeys and the other harboring Schistosoma mansoni, were challenged intrarectally with decreasing doses of R5-tropic clade C simian-human immunodeficiency virus (SHIV-C). Systemic infection occurred in parasitized monkeys at viral doses that remained sub-infectious in normal hosts. In fact, the 50% animal infectious (AID50) SHIV-C dose was 17-fold lower in parasitized animals compared to controls (P<0.001). Coinfected animals also had significantly higher peak viral RNA loads than controls (P<0.001), as well as increased viral replication in CD4+ central memory cells (P = 0.03). Conclusions/Significance: Our data provide the first direct evidence that acute schistosomiasis significantly increases the risk of de novo AIDS virus acquisition, and the magnitude of the effect suggests that control of helminth infections may be a useful public health intervention to help decrease the spread of HIV-1. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi://10.1371/journal.pntd.0000265 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447882/pdf/ en_US
dash.license LAA
dc.subject microbiology en_US
dc.subject parasitology en_US
dc.subject immunity to infections en_US
dc.subject infectious diseases en_US
dc.subject neglected tropical diseases en_US
dc.subject HIV infection and AIDS en_US
dc.subject helminth infections en_US
dc.title Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Neglected Tropical Diseases en_US
dash.depositing.author Ruprecht, Ruth Margrit
dc.date.available 2011-04-25T14:21:22Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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