Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes

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Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes

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Title: Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes
Author: Rui, Yanning; Bai, Jianwu; Perrimon, Norbert

Note: Order does not necessarily reflect citation order of authors.

Citation: Rui, Yanning, Jianwu Bai, and Norbert Perrimon. 2010. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genetics 6(11): e1001208.
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Abstract: The stereotyped striation of myofibrils is a conserved feature of muscle organization that is critical to its function. Although most components that constitute the basic myofibrils are well-characterized biochemically and are conserved across the animal kingdom, the mechanisms leading to the precise assembly of sarcomeres, the basic units of myofibrils, are poorly understood. To gain insights into this process, we investigated the functional relationships of sarcomeric protein complexes. Specifically, we systematically analyzed, using either RNAi in primary muscle cells or available genetic mutations, the organization of myofibrils in Drosophila muscles that lack one or more sarcomeric proteins. Our study reveals that the thin and thick filaments are mutually dependent on each other for striation. Further, the tension sensor complex comprised of zipper/Zasp/α-actinin is involved in stabilizing the sarcomere but not in its initial formation. Finally, integrins appear essential for the interdigitation of thin and thick filaments that occurs prior to striation. Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly.
Published Version: doi:10.1371/journal.pgen.1001208
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987826/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878056

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