Octopamine Neuromodulatory Effects on a Social Behavior Decision-Making Network in Drosophila Males

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Octopamine Neuromodulatory Effects on a Social Behavior Decision-Making Network in Drosophila Males

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dc.contributor.author Certel, Sarah J.
dc.contributor.author Lin, Chih-Yung
dc.contributor.author Perez, Philip
dc.contributor.author Chiang, Ann-Shyn
dc.contributor.author Leung, Adelaine
dc.contributor.author Kravitz, Edward A.
dc.date.accessioned 2011-04-27T01:38:22Z
dc.date.issued 2010
dc.identifier.citation Certel, Sarah J., Adelaine Leung, Chih-Yung Lin, Philip Perez, Ann-Shyn Chiang, and Edward A. Kravitz. 2010. Octopamine neuromodulatory effects on a social behavior decision-making network in drosophila males. PLoS ONE 5(10): e13248. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878059
dc.description.abstract Situations requiring rapid decision-making in response to dynamic environmental demands occur repeatedly in natural environments. Neuromodulation can offer important flexibility to the output of neural networks in coping with changing conditions, but the contribution of individual neuromodulatory neurons in social behavior networks remains relatively unknown. Here we manipulate the Drosophila octopaminergic system and assay changes in adult male decision-making in courtship and aggression paradigms. When the functional state of OA neural circuits is enhanced, males exhibit elevated courtship behavior towards other males in both behavioral contexts. Eliminating the expression of the male form of the neural sex determination factor, Fruitless (FruM), in three OA suboesophageal ganglia (SOG) neurons also leads to increased male-male courtship behavior in these same contexts. We analyzed the fine anatomical structure through confocal examination of labeled single neurons to determine the arborization patterns of each of the three FruM-positive OA SOG neurons. These neurons send processes that display mirror symmetric, widely distributed arbors of endings within brain regions including the ventrolateral protocerebra, the SOG and the peri-esophageal complex. The results suggest that a small subset of OA neurons have the potential to provide male selective modulation of behavior at a single neuron level. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0013248 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953509/pdf/ en_US
dash.license LAA
dc.subject neuroscience en_US
dc.subject developmental biology en_US
dc.subject neurodevelopment en_US
dc.subject behavioral neuroscience en_US
dc.title Octopamine Neuromodulatory Effects on a Social Behavior Decision-Making Network in Drosophila Males en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Kravitz, Edward A.
dc.date.available 2011-04-27T01:38:22Z
dash.affiliation.other HMS^Neurobiology en_US

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