UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions

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UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions

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Title: UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions
Author: Newburger, Daniel E.; Bulyk, Martha Leonia

Note: Order does not necessarily reflect citation order of authors.

Citation: Newburger, Daniel E. and Martha L. Bulyk. 2009. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Research 37: D77-D82.
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Abstract: The UniPROBE (Universal PBM Resource for Oligonucleotide Binding Evaluation) database hosts data generated by universal protein binding microarray (PBM) technology on the in vitro DNA-binding specificities of proteins. This initial release of the UniPROBE database provides a centralized resource for accessing comprehensive PBM data on the preferences of proteins for all possible sequence variants (‘words’) of length k (‘k-mers’), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In total, the database hosts DNA-binding data for over 175 nonredundant proteins from a diverse collection of organisms, including the prokaryote Vibrio harveyi, the eukaryotic malarial parasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, mouse and human. Current web tools include a text-based search, a function for assessing motif similarity between user-entered data and database PWMs, and a function for locating putative binding sites along user-entered nucleotide sequences. The UniPROBE database is available at http://thebrain.bwh.harvard.edu/uniprobe/.
Published Version: doi:10.1093/nar/gkn660
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686578/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878080

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