UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions

UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions

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UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions

dc.contributor.author	Newburger, Daniel E.
dc.contributor.author	Bulyk, Martha Leonia
dc.date.accessioned	2011-04-27T03:39:33Z
dc.date.issued	2009
dc.identifier.citation	Newburger, Daniel E. and Martha L. Bulyk. 2009. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Research 37: D77-D82.	en_US
dc.identifier.issn	0305-1048	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878080
dc.description.abstract	The UniPROBE (Universal PBM Resource for Oligonucleotide Binding Evaluation) database hosts data generated by universal protein binding microarray (PBM) technology on the in vitro DNA-binding specificities of proteins. This initial release of the UniPROBE database provides a centralized resource for accessing comprehensive PBM data on the preferences of proteins for all possible sequence variants (‘words’) of length k (‘k-mers’), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In total, the database hosts DNA-binding data for over 175 nonredundant proteins from a diverse collection of organisms, including the prokaryote Vibrio harveyi, the eukaryotic malarial parasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, mouse and human. Current web tools include a text-based search, a function for assessing motif similarity between user-entered data and database PWMs, and a function for locating putative binding sites along user-entered nucleotide sequences. The UniPROBE database is available at http://thebrain.bwh.harvard.edu/uniprobe/.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Oxford University Press	en_US
dc.relation.isversionof	doi:10.1093/nar/gkn660	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686578/pdf/	en_US
dash.license	LAA
dc.title	UniPROBE: An Online Database of Protein Binding Microarray Data on Protein–DNA Interactions	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Nucleic Acids Research	en_US
dash.depositing.author	Bulyk, Martha Leonia
dc.date.available	2011-04-27T03:39:33Z
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US