Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

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Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

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Title: Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
Author: Blom, Elin S.; Wang, Yijing; Skoglund, Lena; Hansson, Anita C.; Ubaldi, Massimo; Lourdusamy, Anbarasu; Sommer, Wolfgang H.; Mielke, Matthew; Heilig, Markus; Lannfelt, Lars; Nilsson, Lars N. G.; Ingelsson, Martin; Hyman, Bradley Theodore

Note: Order does not necessarily reflect citation order of authors.

Citation: Blom, Elin S., Yijing Wang, Lena Skoglund, Anita C. Hansson, Massimo Ubaldi, Anbarasu Lourdusamy, Wolfgang H. Sommer, et al. 2011. Increased mRNA levels of TCF7L2 and MYC of the Wnt pathway in Tg-ArcSwe mice and Alzheimer's Disease brain. International Journal of Alzheimer's Disease 2011: 936580.
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Abstract: Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P < .05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.
Published Version: doi:10.4061/2011/936580
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014771/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878083

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