Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

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Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

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Title: Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
Author: Plotkin, Lilian I.; Galli, Carlo; Goellner, Joseph J.; Gortazar, Arancha R.; Allen, Matthew R.; Robling, Alexander G.; Turner, Charles H.; Jilka, Robert L.; Weinstein, Robert S.; Manolagas, Stavros C.; Bellido, Teresita; O'Brien, Charles A.; Bouxsein, Mary Larsen; Schipani, Ernestina

Note: Order does not necessarily reflect citation order of authors.

Citation: O'Brien, Charles A., Lilian I. Plotkin, Carlo Galli, Joseph J. Goellner, Arancha R. Gortazar, Matthew R. Allen, Alexander G. Robling, et al. 2008. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 3(8): e2942.
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Abstract: Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone (PTH) stimulates bone remodeling and may cause bone loss or bone gain depending on the balance between bone resorption and formation. Herein, we demonstrate that transgenic mice expressing a constitutively active PTH receptor exclusively in osteocytes exhibit increased bone mass and bone remodeling, as well as reduced expression of the osteocyte-derived Wnt antagonist sclerostin, increased Wnt signaling, increased osteoclast and osteoblast number, and decreased osteoblast apoptosis. Deletion of the Wnt co-receptor LDL related receptor 5 (LRP5) attenuates the high bone mass phenotype but not the increase in bone remodeling induced by the transgene. These findings demonstrate that PTH receptor signaling in osteocytes increases bone mass and the rate of bone remodeling through LRP5-dependent and -independent mechanisms, respectively.
Published Version: doi:10.1371/journal.pone.0002942
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491588/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879204

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