Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study

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Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study

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dc.contributor.author Mohamed, Shajahal
dc.contributor.author Maillard, Pauline
dc.contributor.author Zhu, Yi-Cheng
dc.contributor.author Chabriat, Hugues
dc.contributor.author Mazoyer, Bernard
dc.contributor.author Bousser, Marie-Germaine
dc.contributor.author Dufouil, Carole
dc.contributor.author Tzourio, Christophe
dc.contributor.author Kurth, Tobias
dc.date.accessioned 2011-04-29T04:17:21Z
dc.date.issued 2011
dc.identifier.citation Kurth, Tobias, Shajahal Mohamed, Pauline Maillard, Yi-Cheng Zhu, Hugues Chabriat, Bernard Mazoyer, Marie-Germaine Bousser, Carole Dufouil, and Christophe Tzourio. 2011. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. British Medical Journal 342: c7357. en_US
dc.identifier.issn 0959-8138 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879206
dc.description.abstract Objective: To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and cognition. Design: Population based, cross sectional study. Setting: Epidemiology of Vascular Ageing study, Nantes, France. Participants: 780 participants (mean age 69, 58.5% women) with detailed headache assessment. Main outcome measures: Brain scans were evaluated for volume of white matter hyperintensities (by fully automated imaging processing) and for classification of infarcts (by visual reading with a standardised assessment grid). Cognitive function was assessed by a battery of tests including the mini-mental state examination. Results: 163 (20.9%) participants reported a history of severe headache and 116 had migraine, of whom 17 (14.7%) reported aura symptoms. An association was found between any history of severe headache and increasing volume of white matter hyperintensities. The adjusted odds ratio of being in the highest third for total volume of white matter hyperintensities was 2.0 (95% confidence interval 1.3 to 3.1, P for trend 0.002) for participants with any history of severe headache when compared with participants without severe headache being in the lowest third. The association pattern was similar for all headache types. Migraine with aura was the only headache type strongly associated with volume of deep white matter hyperintensities (highest third odds ratio 12.4, 1.6 to 99.4, P for trend 0.005) and with brain infarcts (3.4, 1.2 to 9.3). The location of infarcts was predominantly outside the cerebellum and brain stem. Evidence was lacking for cognitive impairment for any headache type with or without brain lesions. Conclusions: In this population based study, any history of severe headache was associated with an increased volume of white matter hyperintensities. Migraine with aura was the only headache type associated with brain infarcts. Evidence that headache of any type by itself or in combination with brain lesions was associated with cognitive impairment was lacking. en_US
dc.language.iso en_US en_US
dc.publisher BMJ Publishing Group Ltd. en_US
dc.relation.isversionof doi:10.1136/bmj.c7357 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022913/pdf/ en_US
dash.license LAA
dc.subject epidemiologic studies en_US
dc.subject headache (including migraine) en_US
dc.subject pain (neurology) en_US
dc.subject stroke en_US
dc.subject memory disorders (psychiatry) en_US
dc.subject brain stem en_US
dc.subject cerebellum en_US
dc.title Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMJ: British Medical Journal en_US
dash.depositing.author Kurth, Tobias
dc.date.available 2011-04-29T04:17:21Z
dash.affiliation.other SPH^Epidemiology en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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