Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors

Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors

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Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors

dc.contributor.author	Cannizzo, Elisa
dc.contributor.author	Sadowski, Craig
dc.contributor.author	Bucci, Janessa J.
dc.contributor.author	Carulli, Giovanni
dc.contributor.author	Sohani, Aliyah
dc.contributor.author	Ferry, Judith Ann
dc.contributor.author	Hochberg, Ephraim Paul
dc.contributor.author	Kluk, Michael Joseph
dc.contributor.author	Dorn, Michelle E.
dc.contributor.author	Ackerman, Adam M.
dc.contributor.author	Longtine, Janina Ann
dc.contributor.author	Preffer, Frederic Ira
dc.date.accessioned	2011-05-03T16:12:44Z
dc.date.issued	2009
dc.identifier.citation	Cannizzo, Elisa, Aliyah R. Sohani, Judith A. Ferry, Ephraim P. Hochberg, Michael J. Kluk, Michelle E. Dorn, Craig Sadowski, et al. 2009. Carcinoma and multiple lymphomas in one patient: Establishing the diagnoses and analyzing risk factors. Journal of Hematopathology 2(3): 163-170.	en_US
dc.identifier.issn	1868-9256	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881227
dc.description.abstract	Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung. A 62-year-old man with adenopathy was admitted to the hospital, and lymph node biopsy was positive for low-grade follicular lymphoma. He achieved a partial remission with chemotherapy. Two years later, a PET-CT scan showed a left hilar mass in the lung; biopsy showed a squamous cell carcinoma. Simultaneously, he was diagnosed with diffuse large B cell lymphoma in a neck lymph node; after chemo- and radiotherapy, he achieved a complete response. A restaging PET-CT scan 2 years later revealed a retroperitoneal nodule, and biopsy again showed a low-grade follicular lymphoma, while a biopsy of a cutaneous scalp lesion showed a CD30-positive peripheral T cell lymphoma. After some months, a liver biopsy and a right cervical lymph node biopsy showed a CD30-positive peripheral T cell lymphoma consistent with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. Flow cytometry and cytogenetic and molecular genetic analysis performed at diagnosis and during the patient’s follow-up confirmed the presence of two clonally distinct B cell lymphomas, while the two T cell neoplasms were confirmed to be clonally related. We discuss the relationship between multiple neoplasms occurring in the same patient and the various possible risk factors involved in their development.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Springer-Verlag	en_US
dc.relation.isversionof	doi:10.1007/s12308-009-0041-0	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766444/pdf/	en_US
dash.license	LAA
dc.subject	diffuse large B cell lymphoma	en_US
dc.subject	follicular lymphoma	en_US
dc.subject	anaplastic large cell lymphoma	en_US
dc.subject	risk factors	en_US
dc.subject	multiple malignancies	en_US
dc.subject	cytogenetics	en_US
dc.title	Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Journal of Hematopathology	en_US
dash.depositing.author	Sohani, Aliyah
dc.date.available	2011-05-03T16:12:44Z
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	HMS^Pathology	en_US