Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors

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Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors

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dc.contributor.author Cannizzo, Elisa
dc.contributor.author Sadowski, Craig
dc.contributor.author Bucci, Janessa J.
dc.contributor.author Carulli, Giovanni
dc.contributor.author Sohani, Aliyah
dc.contributor.author Ferry, Judith Ann
dc.contributor.author Hochberg, Ephraim Paul
dc.contributor.author Kluk, Michael Joseph
dc.contributor.author Dorn, Michelle E.
dc.contributor.author Ackerman, Adam M.
dc.contributor.author Longtine, Janina Ann
dc.contributor.author Preffer, Frederic Ira
dc.date.accessioned 2011-05-03T16:12:44Z
dc.date.issued 2009
dc.identifier.citation Cannizzo, Elisa, Aliyah R. Sohani, Judith A. Ferry, Ephraim P. Hochberg, Michael J. Kluk, Michelle E. Dorn, Craig Sadowski, et al. 2009. Carcinoma and multiple lymphomas in one patient: Establishing the diagnoses and analyzing risk factors. Journal of Hematopathology 2(3): 163-170. en_US
dc.identifier.issn 1868-9256 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881227
dc.description.abstract Multiple malignancies may occur in the same patient, and a few reports describe cases with multiple hematologic and non-hematologic neoplasms. We report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung. A 62-year-old man with adenopathy was admitted to the hospital, and lymph node biopsy was positive for low-grade follicular lymphoma. He achieved a partial remission with chemotherapy. Two years later, a PET-CT scan showed a left hilar mass in the lung; biopsy showed a squamous cell carcinoma. Simultaneously, he was diagnosed with diffuse large B cell lymphoma in a neck lymph node; after chemo- and radiotherapy, he achieved a complete response. A restaging PET-CT scan 2 years later revealed a retroperitoneal nodule, and biopsy again showed a low-grade follicular lymphoma, while a biopsy of a cutaneous scalp lesion showed a CD30-positive peripheral T cell lymphoma. After some months, a liver biopsy and a right cervical lymph node biopsy showed a CD30-positive peripheral T cell lymphoma consistent with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. Flow cytometry and cytogenetic and molecular genetic analysis performed at diagnosis and during the patient’s follow-up confirmed the presence of two clonally distinct B cell lymphomas, while the two T cell neoplasms were confirmed to be clonally related. We discuss the relationship between multiple neoplasms occurring in the same patient and the various possible risk factors involved in their development. en_US
dc.language.iso en_US en_US
dc.publisher Springer-Verlag en_US
dc.relation.isversionof doi:10.1007/s12308-009-0041-0 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766444/pdf/ en_US
dash.license LAA
dc.subject diffuse large B cell lymphoma en_US
dc.subject follicular lymphoma en_US
dc.subject anaplastic large cell lymphoma en_US
dc.subject risk factors en_US
dc.subject multiple malignancies en_US
dc.subject cytogenetics en_US
dc.title Carcinoma and Multiple Lymphomas in One Patient: Establishing the Diagnoses and Analyzing Risk Factors en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Hematopathology en_US
dash.depositing.author Sohani, Aliyah
dc.date.available 2011-05-03T16:12:44Z
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US

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