Vestibular Effects on Cerebral Blood Flow

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Vestibular Effects on Cerebral Blood Flow

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dc.contributor.author Schlegel, Todd T
dc.contributor.author Black, F Owen
dc.contributor.author Wood, Scott J
dc.contributor.author Serrador, Jorge Manuel
dc.date.accessioned 2011-05-03T16:18:40Z
dc.date.issued 2009
dc.identifier.citation Serrador, Jorge M., Todd T. Schlegel, F. Owen Black, and Scott J. Wood. 2009. Vestibular effects on cerebral blood flow. BMC Neuroscience 10: 119. en_US
dc.identifier.issn 1471-2202 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881229
dc.description.abstract Background: Humans demonstrate a number of unique adaptations that allow for the maintenance of blood pressure and brain blood flow when upright. While several physiological systems, including cerebral autoregulation, are involved in this adaptation the unique role the vestibular system plays in helping to maintain brain blood flow is just beginning to be elucidated. In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. Results: To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P < 0.01). However, changes in cerebral blood flow were in opposition to changes in blood pressure and not fully dependent on changes in end tidal CO2. Conclusion: The experimental results support our hypothesis and provide evidence that activation of the vestibular apparatus, specifically the otolith organs, directly affects cerebral blood flow regulation, independent of blood pressure and end tidal CO2 changes. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1471-2202-10-119 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758887/pdf/ en_US
dash.license LAA
dc.title Vestibular Effects on Cerebral Blood Flow en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Neuroscience en_US
dash.depositing.author Serrador, Jorge Manuel
dc.date.available 2011-05-03T16:18:40Z
dash.affiliation.other HMS^Neurology-Brigham and Women's Hospital en_US

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