On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies

DSpace/Manakin Repository

On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies

Show simple item record

dc.contributor.author Won, Sungho
dc.contributor.author Mathias, Rasika A.
dc.contributor.author Barnes, Kathleen
dc.contributor.author O'Connor, George T.
dc.contributor.author Wilk, Jemma B
dc.contributor.author O'Donnell, Christopher Joseph
dc.contributor.author Silverman, Edwin Kepner
dc.contributor.author Weiss, Scott Tillman
dc.contributor.author Lange, Christoph
dc.date.accessioned 2011-05-03T20:08:26Z
dc.date.issued 2009
dc.identifier.citation Won, Sungho, Jemma B. Wilk, Rasika A. Mathias, Christopher J. O'Donnell, Edwin K. Silverman, Kathleen Barnes, George T. O'Connor, Scott T. Weiss, and Christoph Lange. 2009. On the analysis of genome-wide association studies in family-based designs: A universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genetics 5(11): e1000741. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881566
dc.description.abstract For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditional family-based approaches that are based exclusively on the within-family information. The approach is suitable for the analysis of almost any trait type, e.g. binary, continuous, time-to-onset, multivariate, etc., and combinations of those. We use simulation studies to verify all theoretically derived properties of the approach, estimate its power, and compare it with other standard approaches. We illustrate the practical implications of the new analysis method by an application to a lung-function phenotype, forced expiratory volume in one second (FEV1) in 4 genome-wide association studies. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1000741 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777973/pdf/ en_US
dash.license LAA
dc.subject genetics and genomics en_US
dc.subject complex traits en_US
dc.subject genetics of disease en_US
dc.title On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author Lange, Christoph
dc.date.available 2011-05-03T20:08:26Z
dash.affiliation.other HMS^Medicine-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Molecular+Integrative Physiological Sci Prog en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Biostatistics en_US

Files in this item

Files Size Format View
2777973.pdf 400.4Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters