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dc.contributor.authorQuintana, Francisco Javier
dc.contributor.authorMimran, Avishai
dc.contributor.authorCarmi, Pnina
dc.contributor.authorMor, Felix
dc.contributor.authorCohen, Irun R.
dc.date.accessioned2011-05-05T16:03:40Z
dc.date.issued2008
dc.identifier.citationQuintana, Francisco J., Avishai Mimran, Pnina Carmi, Felix Mor, and Irun R. Cohen. 2008. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS ONE 3(12): e4026.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4882757
dc.description.abstractThe 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activated T cells was found to be MHC-restricted and dependent on accessory molecules - CD28, CD80 and CD86. Anti-ergotypic T cells responded to T-cell HSP60 by proliferation and secreted IFNγ and TGFβ1. In vitro, the anti-ergotypic T cells inhibited IFNγ production by their activated T-cell targets. In vivo, adoptive transfer of an anti-ergotypic HSP60-specific T-cell line led to decreased secretion of IFNγ by arthritogenic T cells and ameliorated adjuvant arthritis (AA). Thus, the presentation of HSP60 by activated T cells turns them into targets for anti-ergotypic regulatory T cells specific for HSP60. However, the direct interaction between the anti-ergotypic T regulators (anti-HSP60) and the activated T cells also down-regulated the regulators. Thus, by functioning as an ergotope, HSP60 can control both the effector T cells and the regulatory HSP60-specific T cells that control them.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0004026en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602852/pdf/en_US
dash.licenseLAA
dc.subjectimmunologyen_US
dc.subjectautoimmunityen_US
dc.subjectimmune responseen_US
dc.subjectimmunomodulationen_US
dc.titleHSP60 as a Target of Anti-Ergotypic Regulatory T Cellsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorQuintana, Francisco Javier
dc.date.available2011-05-05T16:03:40Z
dash.affiliation.otherHMS^Neurology-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0004026*
dash.contributor.affiliatedQuintana, Francisco


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