dc.contributor.author | Quintana, Francisco Javier | |
dc.contributor.author | Mimran, Avishai | |
dc.contributor.author | Carmi, Pnina | |
dc.contributor.author | Mor, Felix | |
dc.contributor.author | Cohen, Irun R. | |
dc.date.accessioned | 2011-05-05T16:03:40Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Quintana, Francisco J., Avishai Mimran, Pnina Carmi, Felix Mor, and Irun R. Cohen. 2008. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS ONE 3(12): e4026. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882757 | |
dc.description.abstract | The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activated T cells was found to be MHC-restricted and dependent on accessory molecules - CD28, CD80 and CD86. Anti-ergotypic T cells responded to T-cell HSP60 by proliferation and secreted IFNγ and TGFβ1. In vitro, the anti-ergotypic T cells inhibited IFNγ production by their activated T-cell targets. In vivo, adoptive transfer of an anti-ergotypic HSP60-specific T-cell line led to decreased secretion of IFNγ by arthritogenic T cells and ameliorated adjuvant arthritis (AA). Thus, the presentation of HSP60 by activated T cells turns them into targets for anti-ergotypic regulatory T cells specific for HSP60. However, the direct interaction between the anti-ergotypic T regulators (anti-HSP60) and the activated T cells also down-regulated the regulators. Thus, by functioning as an ergotope, HSP60 can control both the effector T cells and the regulatory HSP60-specific T cells that control them. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0004026 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602852/pdf/ | en_US |
dash.license | LAA | |
dc.subject | immunology | en_US |
dc.subject | autoimmunity | en_US |
dc.subject | immune response | en_US |
dc.subject | immunomodulation | en_US |
dc.title | HSP60 as a Target of Anti-Ergotypic Regulatory T Cells | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Quintana, Francisco Javier | |
dc.date.available | 2011-05-05T16:03:40Z | |
dash.affiliation.other | HMS^Neurology-Brigham and Women's Hospital | en_US |
dc.identifier.doi | 10.1371/journal.pone.0004026 | * |
dash.contributor.affiliated | Quintana, Francisco | |