Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

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Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

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dc.contributor.author Hornig, Mady
dc.contributor.author Briese, Thomas
dc.contributor.author Siemetzki, Ulrike
dc.contributor.author Hummel, Kimberly
dc.contributor.author Rota, Paul A.
dc.contributor.author Bellini, William J.
dc.contributor.author Sheils, Orla
dc.contributor.author Alden, Errol
dc.contributor.author Pickering, Larry
dc.contributor.author Lipkin, W. Ian
dc.contributor.author Cookson, Mark R.
dc.contributor.author Buie, Timothy M.
dc.contributor.author Bauman, Margaret Estelle Lang
dc.contributor.author Lauwers, Gregory Y.
dc.contributor.author O'Leary, John J.
dc.date.accessioned 2011-05-06T17:28:16Z
dc.date.issued 2008
dc.identifier.citation Hornig, Mady, Thomas Briese, Timothy Buie, Margaret L. Bauman, Gregory Lauwers, Ulrike Siemetzki, Kimberly Hummel, et al. 2008. Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study. PLoS ONE 3(9). en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882819
dc.description.abstract Background: The presence of measles virus (MV) RNA in bowel tissue from children with autism spectrum disorders (ASD) and gastrointestinal (GI) disturbances was reported in 1998. Subsequent investigations found no associations between MV exposure and ASD but did not test for the presence of MV RNA in bowel or focus on children with ASD and GI disturbances. Failure to replicate the original study design may contribute to continued public concern with respect to the safety of the measles, mumps, and rubella (MMR) vaccine. Methodology/Principal Findings: The objective of this case-control study was to determine whether children with GI disturbances and autism are more likely than children with GI disturbances alone to have MV RNA and/or inflammation in bowel tissues and if autism and/or GI episode onset relate temporally to receipt of MMR. The sample was an age-matched group of US children undergoing clinically-indicated ileocolonoscopy. Ileal and cecal tissues from 25 children with autism and GI disturbances and 13 children with GI disturbances alone (controls) were evaluated by real-time reverse transcription (RT)-PCR for presence of MV RNA in three laboratories blinded to diagnosis, including one wherein the original findings suggesting a link between MV and ASD were reported. The temporal order of onset of GI episodes and autism relative to timing of MMR administration was examined. We found no differences between case and control groups in the presence of MV RNA in ileum and cecum. Results were consistent across the three laboratory sites. GI symptom and autism onset were unrelated to MMR timing. Eighty-eight percent of ASD cases had behavioral regression. Conclusions/Significance: This study provides strong evidence against association of autism with persistent MV RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi://10.1371/journal.pone.0003140 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526159/pdf/ en_US
dash.license LAA
dc.subject public health and epidemiology en_US
dc.subject infectious diseases en_US
dc.subject immunization en_US
dc.subject neurological disorders en_US
dc.subject developmental and pediatric neurology en_US
dc.subject mental health en_US
dc.subject child and adolescent psychiatry en_US
dc.title Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Bauman, Margaret Estelle Lang
dc.date.available 2011-05-06T17:28:16Z
dash.affiliation.other HMS^Neurology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Pathology en_US

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