Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish

DSpace/Manakin Repository

Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish

Citable link to this page

. . . . . .

Title: Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
Author: Iglesias, Antonio H.; Farez, Mauricio F.; Caccamo, Mario; Burns, Evan J.; Kassam, Nasim; Quintana, Francisco Javier; Oukka, Mohamed; Weiner, Howard Lee

Note: Order does not necessarily reflect citation order of authors.

Citation: Quintana, Francisco J., Antonio H. Iglesias, Mauricio F. Farez, Mario Caccamo, Evan J. Burns, Nasim Kassam, Mohamed Oukka, and Howard L. Weiner. 2010. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS ONE 5(3).
Full Text & Related Files:
Abstract: Background: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens is enforced by Foxp3+ regulatory T cells. Recombinatorial mechanisms also operate in teleosts, but active immunoregulation is thought to be a late incorporation to the vertebrate lineage. Methods/Principal Findings: Here we report the characterization of adaptive autoimmunity and Foxp3-based immunoregulation in the zebrafish. We found that zebrafish immunization with an homogenate of zebrafish central nervous system (zCNS) triggered CNS inflammation and specific antibodies. We cloned the zebrafish ortholog for mammalian Foxp3 (zFoxp3) which induced a regulatory phenotype on mouse T cells and controlled IL-17 production in zebrafish embryos. Conclusions/Significance: Our findings demonstrate the acquisition of active mechanisms of self-tolerance early in vertebrate evolution, suggesting that active regulatory mechanisms accompany the development of the molecular potential for adaptive autoimmunity. Moreover, they identify the zebrafish as a tool to study the molecular pathways controlling adaptive immunity.
Published Version: doi://10.1371/journal.pone.0009478
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832694/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882825

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters