p38 MAPK, Microglial Signaling, and Neuropathic Pain

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p38 MAPK, Microglial Signaling, and Neuropathic Pain

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dc.contributor.author Ji, Ru-Rong
dc.contributor.author Suter, Marc
dc.date.accessioned 2011-05-07T23:47:37Z
dc.date.issued 2007
dc.identifier.citation Ji, Ru-Rong, and Marc R Suter. 2007. p38 MAPK, microglial signaling, and neuropathic pain. Molecular Pain 3: 33. en_US
dc.identifier.issn 1744-8069 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882980
dc.description.abstract Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/1744-8069-3-33 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186318/pdf/ en_US
dash.license LAA
dc.title p38 MAPK, Microglial Signaling, and Neuropathic Pain en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Molecular Pain en_US
dash.depositing.author Ji, Ru-Rong
dc.date.available 2011-05-07T23:47:37Z
dash.affiliation.other HMS^Anaesthesia-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Anaesthesia-Brigham and Women's Hospital en_US

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