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dc.contributor.authorMcQueen, Matthew B
dc.contributor.authorBertram, Lars
dc.contributor.authorRimm, Eric B.
dc.contributor.authorBlacker, Deborah Lynne
dc.contributor.authorSantangelo, Susan L.
dc.date.accessioned2011-05-09T04:02:32Z
dc.date.issued2003
dc.identifier.citationMcQueen, Matthew B., Lars Bertram, Eric B. Rimm, Deborah Blacker, and Susan L. Santangelo. 2003. A QTL genome scan of the metabolic syndrome and its component traits. BMC Genetics 4: S96.en_US
dc.identifier.issn1471-2156en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4882988
dc.description.abstractBackground: Because high blood pressure, altered lipid levels, obesity, and diabetes so frequently occur together, they are sometimes collectively referred to as the metabolic syndrome. While there have been many studies of each metabolic syndrome trait separately, few studies have attempted to analyze them combined, i.e., as one composite variable, in quantitative trait linkage or association analysis. We used genotype and phenotype data from the Framingham Heart Study to perform a full-genome scan for quantitative trait loci underlying the metabolic syndrome. Results: Heritability estimates for all of the covariate-adjusted and age- and gender-standardized individual traits, and the composite metabolic syndrome trait, were all fairly high (0.39–0.62), and the composite trait was among the highest at 0.61. The composite trait yielded no regions with suggestive linkage by Lander and Kruglyak's criteria, although there were several noteworthy regions for individual traits, some of which were also observed for the composite variable. Conclusion: Despite its high heritability, the composite metabolic syndrome trait variable did not increase the power to detect or localize linkage peaks in this sample. However, this strategy and related methods of combining correlated individual traits deserve further investigation, particularly in settings with complex causal pathways.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2156-4-S1-S96en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866537/pdf/en_US
dash.licenseLAA
dc.titleA QTL Genome Scan of the Metabolic Syndrome and its Component Traitsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Geneticsen_US
dash.depositing.authorRimm, Eric B.
dc.date.available2011-05-09T04:02:32Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Psychiatry-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/1471-2156-4-S1-S96*
dash.contributor.affiliatedSantangelo, Susan L.
dash.contributor.affiliatedRimm, Eric
dash.contributor.affiliatedBlacker, Deborah


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