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dc.contributor.authorKurth, Tobias
dc.contributor.authorde Jong, Paul E
dc.contributor.authorCook, Nancy Romanowicz
dc.contributor.authorBuring, Julie Elizabeth
dc.contributor.authorRidker, Paul M.
dc.date.accessioned2011-05-10T00:11:49Z
dc.date.issued2009
dc.identifier.citationKurth, Tobias, Paul E. de Jong, Nancy R. Cook, Julie E. Buring, and Paul M. Ridker. 2009. Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study. British Medical Journal 338: b2392.en_US
dc.identifier.issn0959-8138en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4885948
dc.description.abstractObjective: To evaluate the association of kidney function with cardiovascular disease and mortality among apparently healthy women. Design: Prospective cohort study. Setting: Women’s Health Study, United States. Participants: 27 939 female health professionals aged ≥45 who were free of cardiovascular disease and other major disease and who provided a blood sample at study entry. Main outcome measures: Time to cardiovascular disease (non-fatal stroke, non-fatal myocardial infarction, coronary revascularisation procedures, or death from cardiovascular cause), specific cardiovascular disease events, and all-cause mortality. End points were confirmed after review of medical records and death certificates. Results: Glomerular filtration rate (GFR) was estimated with the abbreviated Modification of Diet in Renal Disease Study equation. At baseline, 1315 (4.7%) women had GFR <60 ml/min/1.73 m2. During 12 years of follow-up, 1199 incident cardiovascular disease events and 856 deaths (179 from cardiovascular disease) occurred. Compared with women with GFR ≥90 ml/min/1.73 m2, the multivariable adjusted hazard ratios for any first cardiovascular disease were 0.95 (95% CI 0.83 to 1.08), 0.84 (0.70 to 1.00), and 1.00 (0.79 to 1.27) among women with GFR of 75-89.9, 60-74.9, and <60 ml/min/1.73 m2, respectively; the equivalent hazard ratios for all cause mortality were 0.93 (0.79 to 1.09), 1.03 (0.85 to 1.26), and 1.09 (0.83 to 1.45). Similar null findings were observed for myocardial infarction, stroke, coronary revascularisation, and non-cardiovascular death. However, an increased risk of death from cardiovascular disease was found among women with GFR <60 ml/min/1.73 m2 (hazard ratio 1.68 (1.02 to 2.79)). Conclusions: In this large cohort of women, a glomerular filtration rate <60 ml/min/1.73 m2 was associated with increased risk of cardiovascular disease death but not other cardiovascular disease events or non-cardiovascular disease mortality. We observed no increase in risk of any of the outcomes among women with less severe impairment of kidney function.en_US
dc.language.isoen_USen_US
dc.publisherBMJ Publishing Group Ltd.en_US
dc.relation.isversionofdoi:10.1136/bmj.b2392en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704981/pdf/en_US
dash.licenseLAA
dc.subjectepidemiologic studiesen_US
dc.subjectdrugs: cardiovascular systemen_US
dc.subjectstrokeen_US
dc.subjectdieten_US
dc.subjectischaemic heart diseaseen_US
dc.subjectfluid electrolyte and acid-base disturbancesen_US
dc.titleKidney function and risk of cardiovascular disease and mortality in women: a prospective cohort studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBritish Medical Journalen_US
dash.depositing.authorKurth, Tobias
dc.date.available2011-05-10T00:11:49Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Population Medicineen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1136/bmj.b2392*
dash.contributor.affiliatedKurth, Tobias
dash.contributor.affiliatedCook, Nancy
dash.contributor.affiliatedBuring, Julie
dash.contributor.affiliatedRidker, Paul
dc.identifier.orcid0000-0003-1249-4522


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