Obesity is a modifier of autonomic cardiac responses to fine metal particulates
DSpace/Manakin Repository
Obesity is a modifier of autonomic cardiac responses to fine metal particulates
| Title: | Obesity is a modifier of autonomic cardiac responses to fine metal particulates |
| Author: |
Chen, Jiu-Chiuan; Cavallari, Jennifer Margaret; Stone, Peter Howard; Christiani, David C.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Chen, Jiu-Chiuan, Jennifer M. Cavallari, Peter H. Stone, and David C. Christiani. 2007. Obesity is a modifier of autonomic cardiac responses to fine metal particulates. Environmental Health Perspectives 115(7): 1002-1006. |
| Full Text & Related Files: |
1913600.pdf (133.0Kb; PDF) 
|
| Abstract: | Background: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM\(_{2.5}\) (particulate matter with aero-dynamic diameter ≤2.5 μm), is associated with increased cardiac events and reduction of heart rate variability (HRV).Objectives Our goal was to investigate whether particle-mediated autonomic modulation is aggravated in obese individuals.Methods We examined PM\(_{2.5}\)-mediated acute effects on HRV and heart rate (HR) using 10 24-hr and 13 48-hr ambulatory electrocardiogram recordings collected from 18 boilermakers (39.5 ± 9.1 years of age) exposed to high levels of metal particulates. Average HR and 5-min HRV [SDNN: standard deviation of normal-to-normal intervals (NN); rMSSD: square-root of mean squared-differences of successive NN intervals; HF: high-frequency power 0.15–0.4 Hz] and personal PM\(_{2.5}\) exposures were continuously monitored. Subjects with body mass index ≥ 30 kg/m\(^2\) were classified as obese. Mixed-effect models were used for statistical analyses. Results: Half (50%) of the study subjects were obese. After adjustment for confounders, each 1-mg/m\(^3\) increase in 4-hr moving average PM\(_{2.5}\) was associated with HR increase of 5.9 bpm [95% confidence interval (CI), 4.2 to 7.7] and with 5-min HRV reduction by 6.5% (95% CI, 1.9 to 11.3%) for SDNN, 1.7% (95% CI, –4.9 to 8.4%) for rMSSD, and 8.8% (95% CI, –3.8 to 21.3%) for HF. Obese individuals had greater PM\(_{2.5}\)-mediated HRV reductions (2- to 3-fold differences) than nonobese individuals, and had more PM\(_{2.5}\)-mediated HR increases (9-bpm vs. 4-bpm increase in HR for each 1-mg/m\(^3\) increase in PM\(_{2.5}\); p < 0.001). Conclusions: Our study revealed greater autonomic cardiac responses to metal particulates in obese workers, supporting the hypothesis that obesity may impart greater susceptibility to acute cardiovascular effects of fine particles. |
| Published Version: | doi:10.1289/ehp.9609 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913600/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4885967 |
This item appears in the following Collection(s)
-
HSPH Scholarly Articles [1265]
-
HMS Scholarly Articles [3988]
Contact administrator regarding this item (to report mistakes or request changes)
