Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease

DSpace/Manakin Repository

Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease

Citable link to this page

. . . . . .

Title: Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease
Author: Zanobetti, Antonella; Gold, Diane R.; Stone, Peter Howard; Suh MacIntosh, Helen H.; Schwartz, Joel David; Coull, Brent Andrew; Speizer, Frank Erwin

Note: Order does not necessarily reflect citation order of authors.

Citation: Zanobetti, Antonella, Diane R. Gold, Peter H. Stone, Helen H. Suh, Joel Schwartz, Brent A. Coull, and Frank E. Speizer. 2010. Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease. Environmental Health Perspectives 118(3): 324-330.
Full Text & Related Files:
Abstract: Introduction: Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. Methods: In a repeated-measures study of 46 patients 43–75 years of age, we investigated associations of central-site ambient particulate pollution, including black carbon (BC) (a marker for regional and local traffic), and report of traffic exposure with changes in half-hourly averaged heart rate variability (HRV), a marker of autonomic function measured by 24-hr Holter electrocardiogram monitoring. Each patient was observed up to four times within 1 year after a percutaneous intervention for myocardial infarction, acute coronary syndrome without infarction, or stable coronary artery disease (4,955 half-hour observations). For each half-hour period, diary data defined whether the patient was home or not home, or in traffic. Results: A decrease in high frequency (HF; an HRV marker of vagal tone) of −16.4% [95% confidence interval (CI), −20.7 to −11.8%] was associated with an interquartile range of 0.3-μg/m3 increase in prior 5-day averaged ambient BC. Decreases in HF were independently associated both with the previous 2-hr averaged BC (−10.4%; 95% CI, −15.4 to −5.2%) and with being in traffic in the previous 2 hr (−38.5%; 95% CI, −57.4 to −11.1%). We also observed independent responses for particulate air matter with aerodynamic diameter ≤ 2.5 μm and for gases (ozone or nitrogen dioxide). Conclusion: After hospitalization for coronary artery disease, both particulate pollution and being in traffic, a marker of stress and pollution, were associated with decreased HRV.
Published Version: doi:10.1289/ehp.0901003
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854758/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4885972

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters