Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children

DSpace/Manakin Repository

Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children

Citable link to this page

. . . . . .

Title: Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
Author: Hancock, Dana B.; Romieu, Isabelle; Sienra-Monge, Juan-Jose; Chiu, Grace Y.; Li, Huiling; del Rio-Navarro, Blanca Estela; Willis-Owens, Saffron A. G.; Eng, Celeste; Chapela, Rocio; Burchard, Esteban G.; Tang, Hua; Sullivan, Patrick F.; London, Stephanie J.; Shi, Min; Wu, Hao; Weiss, Scott Tillman; Raby, Benjamin Alexander; Gao, Hong

Note: Order does not necessarily reflect citation order of authors.

Citation: Hancock, Dana B., Isabelle Romieu, Min Shi, Juan-Jose Sienra-Monge, Hao Wu, Grace Y. Chiu, Huiling Li, et al. 2009. Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children. PLoS Genetics 5(8): e1000623.
Full Text & Related Files:
Abstract: Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in 492 Mexican children with asthma, predominantly atopic by skin prick test, and their parents using the Illumina HumanHap 550 K BeadChip to identify novel genetic variation for childhood asthma. The 520,767 autosomal single nucleotide polymorphisms (SNPs) passing quality control were tested for association with childhood asthma using log-linear regression with a log-additive risk model. Eleven of the most significantly associated GWAS SNPs were tested for replication in an independent study of 177 Mexican case–parent trios with childhood-onset asthma and atopy using log-linear analysis. The chromosome 9q21.31 SNP rs2378383 (p = 7.10×10−6 in the GWAS), located upstream of transducin-like enhancer of split 4 (TLE4), gave a p-value of 0.03 and the same direction and magnitude of association in the replication study (combined p = 6.79×10−7). Ancestry analysis on chromosome 9q supported an inverse association between the rs2378383 minor allele (G) and childhood asthma. This work identifies chromosome 9q21.31 as a novel susceptibility locus for childhood asthma in Mexicans. Further, analysis of genome-wide expression data in 51 human tissues from the Novartis Research Foundation showed that median GWAS significance levels for SNPs in genes expressed in the lung differed most significantly from genes not expressed in the lung when compared to 50 other tissues, supporting the biological plausibility of our overall GWAS findings and the multigenic etiology of childhood asthma.
Published Version: doi:10.1371/journal.pgen.1000623
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722731/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4887116

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters