Predictors of Plasma Concentrations of DDE and PCBs in a Group of U.S. Women.

DSpace/Manakin Repository

Predictors of Plasma Concentrations of DDE and PCBs in a Group of U.S. Women.

Citable link to this page

. . . . . .

Title: Predictors of Plasma Concentrations of DDE and PCBs in a Group of U.S. Women.
Author: Neas, L M; Ireland, K; Laden, Francine; Spiegelman, Donna Lynn; Hankinson, Susan Elizabeth; Willett, Walter C.; Wolff, Mary S.; Hunter, David J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Laden, F., L. M. Neas, D. Spiegelman, S. E. Hankinson, W. C. Willett, K. Ireland, M. S. Wolff, and D. J. Hunter. 1999. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environmental Health Perspectives 107(1): 75-81.
Full Text & Related Files:
Abstract: We evaluated predictors of plasma concentrations of dichlorodiphenyldichloroethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), and polychlorinated biphenyls (PCBs) in a group of 240 women, controls from a breast cancer case-control study nested in the Nurses' Health Study. We considered personal attributes such as age, serum cholesterol, region of residence, adiposity, lactation, and dietary intake. DDE levels increased 0.17 ppb/year of age (\(p\) = 0.0003), and PCBs increased 0.08 ppb (\(p\) = 0.0001). DDE and PCBs increased 0.20 (\(p\) = 0.02) and 0.13 ppb (\(p\) = 0.001), respectively, per 10 mg/dl serum cholesterol. Women living in the western United States had higher levels of DDE (mean = 11.0 ppb; \(p\) = 0.003), and women in the Northeast and Midwest had higher levels of PCBs (mean = 5.6 ppb; \(p\) = 0.0002) as compared to women from other parts of the country (mean DDE = 6.3; mean PCBs = 4. 5 ppb). Levels of DDE could not be predicted from consumption of meat, fish, poultry, dairy products, vegetables, fruits, and grains. There was a positive association between fish consumption and PCB concentrations among women in the Northeast and Midwest. Using data from the cases in the nested case-control study to assess the predictive ability of the models, we confirmed that the most reliable predictors of DDE were age and serum cholesterol, and the most important predictors of PCBs were age, serum cholesterol, and residence in the Midwest or Northeast. The null results for the majority of the food variables suggest that specific dietary factors, other than fish, are not currently a substantial contributor to human exposure to DDE and PCBs.
Published Version: doi:10.1289/ehp.9910775
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566315/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889499

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters