Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study

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Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study

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dc.contributor.author Tsaih, Shirng-Wern
dc.contributor.author Aro, Antonio
dc.contributor.author Hu, Howard
dc.contributor.author Korrick, Susan Abigail
dc.contributor.author Schwartz, Joel David
dc.contributor.author Amarasiriwardena, Chitra J.
dc.contributor.author Sparrow, David
dc.date.accessioned 2011-05-15T21:50:38Z
dc.date.issued 2004
dc.identifier.citation Tsaih, Shirng-Wern, Susan Korrick, Joel Schwartz, Chitra Amarasiriwardena, Antonio Aro, David Sparrow, and Howard Hu. 2004. Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study. Environmental Health Perspectives 112(11): 1178-1182. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889506
dc.description.abstract In this prospective study, we examined changes in renal function during 6 years of follow-up in relation to baseline lead levels, diabetes, and hypertension among 448 middle-age and elderly men, a subsample of the Normative Aging Study. Lead levels were generally low at baseline, with mean blood lead, patella lead, and tibia lead values of 6.5 μg/dL, 32.4 μg/g, and 21.5 μg/g, respectively. Six percent and 26% of subjects had diabetes and hypertension at baseline, respectively. In multivariate-adjusted regression analyses, longitudinal increases in serum creatinine (SCr) were associated with higher baseline lead levels but these associations were not statistically significant. However, we observed significant interactions of blood lead and tibia lead with diabetes in predicting annual change in SCr. For example, increasing the tibia lead level from the midpoints of the lowest to the highest quartiles (9–34 μg/g) was associated with an increase in the rate of rise in SCr that was 17.6-fold greater in diabetics than in nondiabetics (1.08 mg/dL/10 years vs. 0.062 mg/dL/10 years; p < 0.01). We also observed significant interactions of blood lead and tibia lead with diabetes in relation to baseline SCr levels (tibia lead only) and follow-up SCr levels. A significant interaction of tibia lead with hypertensive status in predicting annual change in SCr was also observed. We conclude that longitudinal decline of renal function among middle-age and elderly individuals appears to depend on both long-term lead stores and circulating lead, with an effect that is most pronounced among diabetics and hypertensives, subjects who likely represent particularly susceptible groups. en_US
dc.language.iso en_US en_US
dc.publisher National Institue of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.7024 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247478/pdf/ en_US
dash.license LAA
dc.subject blood lead en_US
dc.subject bone lead en_US
dc.subject diabetes en_US
dc.subject hypertension en_US
dc.subject kidney function en_US
dc.subject serum creatinine en_US
dc.title Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Korrick, Susan Abigail
dc.date.available 2011-05-15T21:50:38Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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