Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen

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Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen

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dc.contributor.author Thompson, Aaron M.S.
dc.contributor.author Silverman, Frances
dc.contributor.author Urch, Bruce
dc.contributor.author Speck, Mary
dc.contributor.author Brook, Jeffrey R.
dc.contributor.author Manno, Michael
dc.contributor.author Zanobetti, Antonella
dc.contributor.author Schwartz, Joel David
dc.contributor.author Coull, Brent Andrew
dc.contributor.author Gold, Diane R.
dc.date.accessioned 2011-05-16T23:28:08Z
dc.date.issued 2009
dc.identifier.citation Thompson, Aaron M. S., Antonella Zanobetti, Frances Silverman, Joel Schwartz, Brent Coull, Bruce Urch, Mary Speck, Jeffrey R. Brook, Michael Manno, and Diane R. Gold. 2010. Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen. Environmental Health Perspectives 118(1): 120-124. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889575
dc.description.abstract Introduction: Systemic inflammation may be one of the mechanisms mediating the association between ambient air pollution and cardiovascular morbidity and mortality. Interleukin-6 (IL-6) and fibrinogen are biomarkers of systemic inflammation that are independent risk factors for cardiovascular disease. Objective: We investigated the association between ambient air pollution and systemic inflammation using baseline measurements of IL-6 and fibrinogen from controlled human exposure studies. Methods: In this retrospective analysis we used repeated-measures data in 45 nonsmoking subjects. Hourly and daily moving averages were calculated for ozone, nitrogen dioxide, sulfur dioxide, and particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5). Linear mixed-model regression determined the effects of the pollutants on systemic IL-6 and fibrinogen. Effect modification by season was considered. Results: We observed a positive association between IL-6 and O3 [0.31 SD per O3 interquartile range (IQR); 95% confidence interval (CI), 0.08–0.54] and between IL-6 and SO2 (0.25 SD per SO2 IQR; 95% CI, 0.06–0.43). We observed the strongest effects using 4-day moving averages. Responses to pollutants varied by season and tended to be higher in the summer, particularly for O3 and PM2.5. Fibrinogen was not associated with pollution. Conclusions: This study demonstrates a significant association between ambient pollutant levels and baseline levels of systemic IL-6. These findings have potential implications for controlled human exposure studies. Future research should consider whether ambient pollution exposure before chamber exposure modifies IL-6 response. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.0900550 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831955/pdf/ en_US
dash.license LAA
dc.subject air pollution en_US
dc.subject epidemiology en_US
dc.subject fibrinogen en_US
dc.subject inflammation en_US
dc.subject interleukin-6 en_US
dc.title Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Zanobetti, Antonella
dc.date.available 2011-05-16T23:28:08Z
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other SPH^Biostatistics en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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