Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity

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Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity

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dc.contributor.author Kang, Kihwa
dc.contributor.author Zhang, Cuilin
dc.contributor.author Kraft, Peter
dc.contributor.author Qi, Lu
dc.contributor.author Hunter, David G.
dc.contributor.author van Dam, Rob M.
dc.contributor.author Lee, Chih-Hao
dc.contributor.author Hu, Frank B.
dc.date.accessioned 2011-05-16T23:51:33Z
dc.date.issued 2008
dc.identifier.citation Qi, Lu, Kihwa Kang, Cuilin Zhang, Rob M. van Dam, Peter Kraft, David Hunter, Chih-Hao Lee, and Frank B. Hu. 2008. Fat Mass- and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity. Diabetes 57(11): 3145-3151. en_US
dc.identifier.issn 0012-1797 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889587
dc.description.abstract OBJECTIVE—To examine the longitudinal association of fat mass–and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN AND METHODS—We genotyped rs9939609 in 2,287 men and 3,520 women from two prospective cohorts. Plasma adiponectin and leptin were measured in a subset of diabetic men (n = 854) and women (n = 987). Expression of FTO was tested in adipocytes from db/db mice and mouse macrophages. RESULTS—We observed a trend toward decreasing associations between rs9939609 and BMI at older age (≥65 years) in men, whereas the associations were constant across different age groups in women. In addition, the single nucleotide polymorphism (SNP) rs9939609 was associated with lower plasma adiponectin (log[e]− means, 1.82 ± 0.04, 1.73 ± 0.03, and 1.68 ± 0.05 for TT, TA, and AA genotypes, respectively; P for trend = 0.02) and leptin (log[e]− means, 3.56 ± 0.04, 3.63 ± 0.04, and 3.70 ± 0.06; P for trend = 0.06) in diabetic women. Adjustment for BMI attenuated the associations. FTO gene was universally expressed in human and mice tissues, including adipocytes. In an ancillary study of adipocytes from db/db mice, FTO expression was ∼50% lower than in those from wild-type mice. CONCLUSIONS—The association between FTO SNP rs9939609 and obesity risk may decline at older age. The variant affects circulating adiponectin and leptin levels through the changes in BMI. In addition, the expression of FTO gene was reduced in adipocytes from db/db mice. en_US
dc.language.iso en_US en_US
dc.publisher American Diabetes Association en_US
dc.relation.isversionof doi:10.2337/db08-0006 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570413/pdf/ en_US
dash.license LAA
dc.title Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Diabetes en_US
dash.depositing.author Qi, Lu
dc.date.available 2011-05-16T23:51:33Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Nutrition en_US
dash.affiliation.other SPH^Nutrition en_US
dash.affiliation.other HMS^Ophthalmology en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Nutrition en_US

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