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dc.contributor.authorPrice, Alkes
dc.contributor.authorTandon, Arti
dc.contributor.authorPatterson, Nick
dc.contributor.authorBarnes, Kathleen C.
dc.contributor.authorRafaels, Nicholas
dc.contributor.authorRuczinski, Ingo
dc.contributor.authorBeaty, Terri H.
dc.contributor.authorMathias, Rasika
dc.contributor.authorReich, David Emil
dc.contributor.authorMyers, Simon
dc.date.accessioned2011-05-17T00:00:04Z
dc.date.issued2009
dc.identifier.citationPrice, Alkes L., Arti Tandon, Nick Patterson, Kathleen C. Barnes, Nicholas Rafaels, Ingo Ruczinski, Terri H. Beaty, Rasika Mathias, David Reich, and Simon Myers. 2009. Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations. PLoS Genetics 5(6): e1000519.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889591
dc.description.abstractIdentifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease mapping to learning about history. Most methods require the use of unlinked markers; but, using all markers from genome-wide scanning arrays, it should in principle be possible to infer the ancestry of even very small segments with exquisite accuracy. We describe a method, HAPMIX, which employs an explicit population genetic model to perform such local ancestry inference based on fine-scale variation data. We show that HAPMIX outperforms other methods, and we explore its utility for inferring ancestry, learning about ancestral populations, and inferring dates of admixture. We validate the method empirically by applying it to populations that have experienced recent and ancient admixture: 935 African Americans from the United States and 29 Mozabites from North Africa. HAPMIX will be of particular utility for mapping disease genes in recently admixed populations, as its accurate estimates of local ancestry permit admixture and case-control association signals to be combined, enabling more powerful tests of association than with either signal alone.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1000519en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689842/pdf/en_US
dash.licenseLAA
dc.subjectgenetics and genomicsen_US
dc.subjectbioinformaticsen_US
dc.subjectgenetics of diseaseen_US
dc.subjectpopulation geneticsen_US
dc.subjectmathematicsen_US
dc.subjectstatisticsen_US
dc.titleSensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populationsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorPrice, Alkes
dc.date.available2011-05-17T00:00:04Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Geneticsen_US
dash.affiliation.otherHMS^Geneticsen_US
dc.data.urihttp://hdl.handle.net/1902.1/15245en_US
dc.data.urihttp://hdl.handle.net/1902.1/15248en_US
dc.identifier.doi10.1371/journal.pgen.1000519*
dash.contributor.affiliatedTandon, Arti
dash.contributor.affiliatedPrice, Alkes
dash.contributor.affiliatedReich, David


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