Unanswered ethical and scientific questions for trials of invasive interventions for coronary disease: The case of single vessel disease

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Unanswered ethical and scientific questions for trials of invasive interventions for coronary disease: The case of single vessel disease

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dc.contributor.author Jabbour, Samer
dc.contributor.author Ravid, Shmuel M.D.
dc.contributor.author Lown, Bernard
dc.date.accessioned 2011-05-18T23:00:07Z
dc.date.issued 2004
dc.identifier.citation Jabbour, Samer, Shmuel Ravid, and Bernard Lown. 2004. Unanswered ethical and scientific questions for trials of invasive interventions for coronary disease: The case of single vessel disease. Current Controlled Trials in Cardiovascular Medicine 5(1): 2. en_US
dc.identifier.issn 1468-6708 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4891645
dc.description.abstract Trials in the 1990s demonstrated that medical therapy is as effective as invasive therapies for treating single-vessel coronary disease. Yet more recent studies enrolling patients with this condition have focused on evaluating only invasive approaches, namely, stenting versus coronary artery bypass surgery. Several ethical and scientific questions remain unanswered regarding the conduct of these later trials. Were they justified? Why wasn't a medical therapy arm included? Were subjects informed about the availability of medical therapy as an equivalent option? Was optimized medical therapy given prior to randomization? The absence of clear answers to these questions raises the possibility of serious bias in favor of invasive interventions. Considering that medical therapy is underutilized in patients with coronary disease, efforts should focus more on increasing utilization of medical therapy and proper selection of noninvasive interventions. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1468-6708-5-2 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395789/pdf/ en_US
dash.license LAA
dc.title Unanswered ethical and scientific questions for trials of invasive interventions for coronary disease: The case of single vessel disease en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Current Controlled Trials in Cardiovascular Medicine en_US
dash.depositing.author Ravid, Shmuel M.D.
dc.date.available 2011-05-18T23:00:07Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Nutrition en_US
dash.affiliation.other SPH^Nutrition en_US

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