Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City

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Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City

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dc.contributor.author Meeker, John D.
dc.contributor.author Hu, Howard
dc.contributor.author Cantonwine, David E.
dc.contributor.author Lamadrid-Figueroa, Hector
dc.contributor.author Calafat, Antonia M.
dc.contributor.author Loch-Caruso, Rita
dc.contributor.author Téllez-Rojo, Martha María
dc.contributor.author Ettinger, Adrienne S
dc.contributor.author Hernandez-Avila, Mauricio
dc.date.accessioned 2011-05-19T01:03:40Z
dc.date.issued 2009
dc.identifier.citation Meeker, John D., Howard Hu, David E. Cantonwine, Hector Lamadrid-Figueroa, Antonia M. Calafat, Adrienne S. Ettinger, Mauricio Hernandez-Avila, Rita Loch-Caruso, and Martha Téllez-Rojo. 2009. Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City. Environmental Health Perspectives 117(10): 1587-1592. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4891666
dc.description.abstract Background: Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. Objective: We investigated the relationship between phthalate exposure and preterm birth. Methods: Within a large Mexican birth cohort study, we compared third-trimester urinary phthalate metabolite concentrations in 30 women who delivered preterm (< 37 weeks of gestation) with those of 30 controls (≥ 37 weeks of gestation). Results: Concentrations of most of the metabolites were similar to those reported among U.S. females, although in the present study mono-n-butyl phthalate (MBP) concentrations were higher and monobenzyl phthalate (MBzP) concentrations lower. In a crude comparison before correcting for urinary dilution, geometric mean urinary concentrations were higher for the phthalate metabolites MBP, MBzP, mono(3-carboxylpropyl) phthalate, and four metabolites of di(2-ethyl-hexyl) phthalate among women who subsequently delivered preterm. These differences remained, but were somewhat lessened, after correction by specific gravity or creatinine. In multivariate logistic regression analysis adjusted for potential confounders, elevated odds of having phthalate metabolite concentrations above the median level were found. Conclusions: We found that phthalate exposure is prevalent among this group of pregnant women in Mexico and that some phthalates may be associated with preterm birth. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.0800522 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790514/pdf/ en_US
dash.license LAA
dc.subject case–control en_US
dc.subject environment en_US
dc.subject epidemiology en_US
dc.subject exposure en_US
dc.subject pregnancy en_US
dc.subject prematurity en_US
dc.subject children's health en_US
dc.title Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Ettinger, Adrienne S
dc.date.available 2011-05-19T01:03:40Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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