Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water

DSpace/Manakin Repository

Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water

Show simple item record

dc.contributor.author Bouchard, Maryse
dc.contributor.author Laforest, François
dc.contributor.author Vandelac, Louise
dc.contributor.author Mergler, Donna
dc.contributor.author Bellinger, David C.
dc.date.accessioned 2011-05-19T19:47:25Z
dc.date.issued 2006
dc.identifier.citation Bouchard, Maryse, François Laforest, Louise Vandelac, David Bellinger, and Donna Mergler. 2007. Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water. Environmental Health Perspectives 115(1): 122-127. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4892215
dc.description.abstract Background: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where naturally occurring high Mn levels were present in the public water system. Our objective was to test the hypothesis that greater exposure to Mn via drinking water would be reflected in higher Mn content in hair which, in turn, would be associated with increased level of hyperactive behaviors. Methods: Forty-six children participated in the study, 24 boys and 22 girls, 6–15 years of age (median, 11 years). Their homes received water from one of two wells (W) with different Mn concentrations: W1: mean 610 μg/L; W2: mean 160 μg/L. The Revised Conners’ Rating Scale for parents (CPRS-R) and for teachers (CTRS-R) were administered, providing T-scores on the following subscales: Oppositional, Hyperactivity, Cognitive Problems/Inattention, and ADHD Index. Results: Children whose houses were supplied by W1 had higher hair Mn (MnH) than those supplied by W2 (mean 6.2 ± 4.7 μg/g vs. 3.3 ± 3.0 μg/g, p = 0.025). MnH was significantly associated with T-scores on the CTRS-R Oppositional (p = 0.020) and Hyperactivity (p = 0.002) subscales, after adjustment for age, sex, and income. All children with Oppositional and Hyperactivity T-scores ≥ 65 had MnH > 3.0 μg/g. Conclusions: The findings of this pilot study are sufficiently compelling to warrant more extensive investigations into the risks of Mn exposure in drinking water. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.9504 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797845/pdf/ en_US
dash.license LAA
dc.subject children en_US
dc.subject children's health en_US
dc.subject CPRS-R en_US
dc.subject CTRS-R en_US
dc.subject hair en_US
dc.subject hyperactive behaviors en_US
dc.subject manganese en_US
dc.subject well water en_US
dc.title Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Bellinger, David C.
dc.date.available 2011-05-19T19:47:25Z
dash.affiliation.other HMS^Neurology-Children's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

Files in this item

Files Size Format View
1797845.pdf 513.7Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters