The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
DSpace/Manakin Repository
The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
| Title: | The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity |
| Author: |
Lieberman, Linda Adelle; Tsokos, George C.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Lieberman, Linda A., and George C. Tsokos. 2010. The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity. Journal of Biomedicine and Biotechnology 2010: 740619. |
| Full Text & Related Files: |
2896881.pdf (575.5Kb; PDF) 
|
| Abstract: | IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased Treg production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease. |
| Published Version: | doi://10.1155/2010/740619 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896881/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4911702 |
This item appears in the following Collection(s)
-
HMS Scholarly Articles [4020]
Contact administrator regarding this item (to report mistakes or request changes)
