Browsing FAS Theses and Dissertations by Title
Now showing items 1278-1297 of 6136
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Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
(2015-05-17)Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ... -
Disentangling the Roles of Form and Motion in Fish Swimming Performance
(2017-05-11)A central theme of comparative biomechanics is linking patterns of variation in morphology with variation in locomotor performance. This presents a unique challenge in fishes, given their extraordinary morphological diversity ... -
Disordered proteins regulate stress- & damage-dependent DNA binding
(2023-01-18)Three-dimensional structure has been used as a starting point to characterize protein function since the advent of X-ray crystallography in the 1950s. However, not all proteins bear stable tertiary or even secondary ... -
Disorientations. Latin American Fictions of East Asia
(2014-06-06)This dissertation explores the relationship between fiction, knowledge and "knowing" in Latin American discourses of China and Japan. By scrutinizing Brazilian and Hispanic American travel journals, novels, short stories ... -
disparate space, shared space
(2017-05-12)This dissertation is the result of seven years of creative work, during which ten new musical compositions were conceived, produced, and premiered. Eight of these are represented herein. A portfolio of works brought into ... -
Disposable Subjects: Law and Child Migration to the United States, 1890s-1920s
(2022-03-17)Disposable Subjects argues that foreign-born minors at the US border found themselves increasingly at the disposal of others, first and foremost the state, from the late nineteenth century to the 1920s. It explores the ... -
Disputing the Acoustic Territory: Politics of Sound and Sonic Order in 16th and 17th century Mexico City
(2023-06-01)Disputing the Acoustic Territory examines the importance of urban sounds—such as bell ringings, town criers, market bustles, and street musicians—in marking communal rhythms, controlling individuals’ sense of time, and ... -
Disruption of mammalian SWI/SNF chromatin remodeler function in human disease
(2023-11-21)The regulation of chromatin architecture and accessibility is central to the control of gene expression programs that govern cellular identity, cell fate and lineage commitment, differentiation, and responses to stimuli. ... -
Disruption of Mitochondrial Dynamics in Tauopathy
(2013-02-06)Alzheimer’s disease (AD) is characterized pathologically by proteinaceous aggregates composed primarily of amyloid \(\beta (A \beta)\) and tau. Diseases characterized by abnormal deposition of tau are collectively termed ... -
Dissecting and Targeting the PUMA and OLIG2 Control Points of Tumors of Neuroectodermal Origin with Stapled Peptides
(2013-09-30)Tumors of neuroectodermal origin are among the most aggressive and treatment-refractory forms of human cancer. While such tumors arise from a variety of defects, two key targets are the transcription factors p53 and OLIG2. ... -
Dissecting Molecular Mechanisms of Shigella flexneri Cell-to-cell Spread
(2014-10-21)Shigella is a causative agent of bacillary dysentery in humans. The ability of Shigella to disseminate in the intestinal epithelium is crucial for disease establishment. This process of cell-to-cell spread involves actin-based ... -
Dissecting Molecular Similarities and Differences Between Pluripotent Stem Cell Lines
(2015-05-16)Traditionally, pluripotent stem cells are derived from preimplantation embryos and fetal germ cells, which give rise to embryonic stem cells (ESCs) and embryonic germ cells (EGCs), respectively, In contrast, induced ... -
Dissecting Motor Adaptation in Visually Guided Reaching Movements
(2012-11-06)Movement is essential to human life because it provides us with the freedom of mobility and the power to affect our surroundings. Moreover, movements are vital to communication: from hand and finger movements when writing, ... -
Dissecting Multiscale Interplay between Chromatin Organization and Gene Expression
(2023-03-14)Chromosomes in eukaryote nuclei of cells store genetic information. How chromosomes are organized and how does chromatin organization regulate cellular functions especially transcription has been a long-standing question ... -
Dissecting Olfactory Circuits in Drosophila
(2014-06-06)Drosophila is a simple and genetically tractable model system for studying neural circuits. This dissertation consists of two studies, with the broad goal of understanding sensory processing in neural circuits using ... -
Dissecting Protein-Protein Interactions that Regulate the Spindle Checkpoint in Budding Yeast
(2013-03-05)Errors in segregation of genetic materials are detrimental to all organisms. The budding yeast ensures accurate chromosome segregation by employing a system called the spindle checkpoint. The spindle checkpoint, which ... -
Dissecting the Composition of Striatal Dopamine Release Machinery
(2021-11-16)There are two general modes of neurotransmission. In synaptic transmission, neurotransmitter-filled vesicles are rapidly released, and the signal is sensed by the target cell in a spatially and temporally precise manner. ... -
Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice
(2021-09-10)DNA methylation is a remarkably dynamic repressive DNA modification that can be stably propagated over successive cell divisions and forms an essential layer of the epigenetic landscape that defines each cell. In the early ... -
Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX
(2013-10-08)Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX -
Dissecting the molecular mechanisms of cellular injury in the kidney
(2023-06-01)More than 850 million people are affected by chronic kidney disease (CKD) globally. Despite the prevalence of CKD, there are few options for treatment apart from dialysis or kidney transplantation. The complexities underlying ...