Browsing FAS Theses and Dissertations by Title
Now showing items 1461-1480 of 6097
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Elucidating the Mechanism of Small-molecule-induced Protein Degradation for Targeted Cancer Therapy
(2021-05-13)Small-molecule-based targeted cancer therapies should ideally exert complete and sustained pharmacological inhibition of their respective targets. This is often challenging to achieve, given that many targets implicated ... -
Elucidating the Reactivity of Open-Shell Polynuclear Iron Hydride Clusters
(2023-06-01)Polynuclear reaction sites are used by metalloenzymes as well as heterogeneous catalysts to facilitate multi-electron small molecule activation via cooperative redox chemistry. Specifically, polynuclear transition metal ... -
Elucidating the Regulation and Effectors of the Breast Cancer Oncogene, IKKepsilon
(2012-12-19)The IkappaB kinase epsilon (IKKepsilon, IKKi, IKBKE) is both a regulator of innate immunity and a breast cancer oncogene that is amplified and overexpressed in ~30% of breast cancers. IKKepsilon promotes malignant ... -
Elucidating the Role of RasGAP Genes as Tumor Suppressors in Breast Cancer
(2017-05-10)RAS genes are commonly mutated in human cancers and aberrant Ras activation drives tumorigenesis. However, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and its effectors, suggesting that ... -
Elucidating the virulence control network in Francisella tularensis
(2014-06-06)The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia and a model intracellular pathogen. It is also considered a potential bioweapon, as F. tularensis is highly infectious and has the ... -
Elucidation of immune cell function via nanotechnology and single-cell profiling.
(2014-06-06)A healthy immune system's core challenge is to mount appropriate responses to an immense and unknown variety of antigenic stimuli. By unraveling the regulatory networks that drive and control immune-cell behaviors, we can ... -
Elucidation of Mechanisms of Fetal Hemoglobin Regulation by CRISPR/Cas9 Mediated Genome Editing
(2016-03-14)Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Fetal hemoglobin (HbF) reinduction represents a “silver bullet” for ... -
Elucidation of plasmacytoid dendritic cell development
(2014-06-06)Most currently defined hematopoietic progenitor pools are heterogeneous, contributing to uncertainty regarding the development of certain blood cells. The origins of plasmacytoid dendritic cells, for instance, have long ... -
Elucidation of the Cation−π Interaction in Small-Molecule Asymmetric Catalysis
(2013-10-14)The cation–π interaction has been long-established to play an important role in molecular recognition, supramolecular chemistry, and molecular biology. In contrast, its potential application in small-molecule ... -
Embedded 3D Printing of Polymeric and Ceramic Lattices
(2023-03-14)From the insulating properties of cork to the high strength of lightweight bird bones, lattices with exceptional properties are abundant in nature. These natural structures are constructed of materials spanning from purely ... -
Embedded Dense Neural Networks for Battery Cyclability Prediction on Automotive Microcontroller Devices
(2021-06-03)Recent increase in energy demand has resulted in an upsurge of interest in developing efficient battery storage systems and designing scalable machine learning models that predict the performance of these batteries. This ... -
Embodying Musicality through Irish Dance
(2022-06-06)This study is an ethnography of the adult non-competitive Irish dance community in Boston, in which I explore the multi-modal nature of musical experience through an investigation of dance practices and transmission. As a ... -
Embracing Compliance and Instabilities to Achieve Function in Mechanical Metamaterials and Devices
(2016-04-26)The use of soft materials has led to the development of soft devices that have the potential to be more robust, adaptable, and safer for human interaction than traditional rigid systems. State-of-the-art developments push ... -
Embracing Uncertainty as the New Norm: A Risk-Based Portfolio Approach for Urban Water Investment Planning
(2016-01-26)Providing secure and reliable water supply service to major urban areas has become a considerable challenge in recent years on a global basis. Rapid population growth, urbanization and development needs put enormous ... -
Emergence of Reward Coding in the Olfactory System
(2016-05-17)Identifying dangerous or rewarding elements in an animal’s surroundings is an important – if not primary – function of sensory systems. This holds particularly true for the mouse olfactory system since odors convey crucial ... -
Emergence of rich visual features from general architectural and learning constraints
(2023-05-11)The human visual system supports a wide variety of behavioral capacities including categorizing objects, reading written symbols, comparing numerosities, and detecting social interactions. What constraints and forms of ... -
Emergence of simian immunodeficiency virus in rhesus macaques is characterized by changes in structural and accessory genes that enhance fitness in the new host species
(2016-02-25)The distribution of lentiviruses among primates reflects a history of interspecies transmission and emergence of new virus-host relationships. The degree to which viruses must adapt to the genetic environment of new host ... -
The Emergence of ʿIlm al-Bayān: Classical Arabic Literary Theory in the Arabic East in the 7th/13th Century
(2016-09-12)This dissertation identifies a turning point in the development of literary theory as a discipline in the classical Arabic-Islamic world, starting in the Arabic East in the thirteenth century under the emerging framework ... -
Emergent and topological phenomena in many-body systems: Quantum spin liquids and beyond
(2021-09-03)Emergence refers to the phenomena in many-body systems not obvious from microscopic details and fundamental laws. In this dissertation, I will present some of the works that study exotic emergent phe- nomena. In the first ...