Browsing FAS Theses and Dissertations by Title
Now showing items 1466-1485 of 6136
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Elemental Mediations: Art, Cinema, and Performance in Contemporary China
(2022-05-20)Elemental Mediations is an ethnographic study of artists who work in the fields of popular performance, independent cinema, and contemporary art in China. Drawing on two years of fieldwork, I use the concept of “elemental ... -
Elicitation of antibody responses against the HIV-1 gp41 Membrane Proximal External Region (MPER)
(2014-06-06)An effective vaccine to protect against HIV-1/AIDS remains elusive due to the extensive mechanisms employed by the HIV-1 virus to evade immune attack. Highly potent broadly neutralizing antibodies isolated from chronically ... -
Eliciting and Aggregating Truthful and Noisy Information
(2014-10-21)In the modern world, making informed decisions requires obtaining and aggregating relevant information about events of interest. For many political, business, and entertainment events, the information of interest only ... -
Elite Consensus and Rising Power Foreign Policy: China's active management of security disputes with Japan, South Korea and the Philippines
(2020-11-23)How can a rising power avoid violent confrontations with the dominant power and continue rising? Not all power transitions are accompanied by war between the dominant and rising powers. This dissertation studies a rising ... -
Elucidating CTCF-Mediated Regulation of V(D)J Recombination at the Immunoglobulin Heavy Chain Locus
(2017-09-08)Immunoglobulin heavy (IgH) and light (IgL) chains associate to form the B cell receptor (BCR), which is secreted as an antibody upon B cell activation. Each B cell generates and expresses a unique set of IgH and IgL variable ... -
Elucidating Determining Factors in Heterogeneous Catalysis Using Surface Science Models
(2020-08-11)This thesis investigates fundamental interactions between catalyst surfaces and adsorbates that can affect the performance of heterogeneous catalysts by using controlled, model surface science studies. These interactions ... -
Elucidating Influences of Substrate DNA Sequences on AID Targeting and Outcome During Antibody Maturation
(2017-04-20)During antibody maturation, Activation Induced Cytidine Deaminase (AID) initiates antibody variable (V) exon somatic hypermutation (SHM) for affinity maturation in germinal centers (GCs) and IgH switch (S) region DNA breaks ... -
Elucidating Mechanisms of IgH Class Switch Recombination Involving Switch Regions and Double Strand Break Joining
(2013-02-22)During IgH class switch recombination (CSR) in mature B lymphocytes, activation-induced cytidine deaminase (AID) initiates DNA double strand breaks (DSBs) within switch (S) regions flanking different sets of the IgH locus ... -
Elucidating mechanisms of microbiome-diet modulation of host homeostasis
(2023-11-21)Industrialization and advances in technology over the last half-millennium have led to dramatic changes in human society. The diet of our ancestors, once rich in plant matter of extraordinary chemical diversity, has been ... -
Elucidating Pathways of Classical and Alternative Pathways of Non-Homologous End-Joining in B-Lymphocytes
(2017-05-10)DNA double-stranded breaks (DSBs), if not properly repaired, drive genomic instability. Accordingly, mammalian cells employ classical non-homologous end-joining (C-NHEJ) to repair DSBs generated throughout interphase, ... -
Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ... -
Elucidating the Mechanism of Small-molecule-induced Protein Degradation for Targeted Cancer Therapy
(2021-05-13)Small-molecule-based targeted cancer therapies should ideally exert complete and sustained pharmacological inhibition of their respective targets. This is often challenging to achieve, given that many targets implicated ... -
Elucidating the Reactivity of Open-Shell Polynuclear Iron Hydride Clusters
(2023-06-01)Polynuclear reaction sites are used by metalloenzymes as well as heterogeneous catalysts to facilitate multi-electron small molecule activation via cooperative redox chemistry. Specifically, polynuclear transition metal ... -
Elucidating the Regulation and Effectors of the Breast Cancer Oncogene, IKKepsilon
(2012-12-19)The IkappaB kinase epsilon (IKKepsilon, IKKi, IKBKE) is both a regulator of innate immunity and a breast cancer oncogene that is amplified and overexpressed in ~30% of breast cancers. IKKepsilon promotes malignant ... -
Elucidating the Role of RasGAP Genes as Tumor Suppressors in Breast Cancer
(2017-05-10)RAS genes are commonly mutated in human cancers and aberrant Ras activation drives tumorigenesis. However, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and its effectors, suggesting that ... -
Elucidating the virulence control network in Francisella tularensis
(2014-06-06)The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia and a model intracellular pathogen. It is also considered a potential bioweapon, as F. tularensis is highly infectious and has the ... -
Elucidation of immune cell function via nanotechnology and single-cell profiling.
(2014-06-06)A healthy immune system's core challenge is to mount appropriate responses to an immense and unknown variety of antigenic stimuli. By unraveling the regulatory networks that drive and control immune-cell behaviors, we can ... -
Elucidation of Mechanisms of Fetal Hemoglobin Regulation by CRISPR/Cas9 Mediated Genome Editing
(2016-03-14)Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Fetal hemoglobin (HbF) reinduction represents a “silver bullet” for ... -
Elucidation of plasmacytoid dendritic cell development
(2014-06-06)Most currently defined hematopoietic progenitor pools are heterogeneous, contributing to uncertainty regarding the development of certain blood cells. The origins of plasmacytoid dendritic cells, for instance, have long ... -
Elucidation of the Cation−π Interaction in Small-Molecule Asymmetric Catalysis
(2013-10-14)The cation–π interaction has been long-established to play an important role in molecular recognition, supramolecular chemistry, and molecular biology. In contrast, its potential application in small-molecule ...