Browsing FAS Theses and Dissertations by Title
Now showing items 354-373 of 6136
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Assembling the Cure: Materia Medica and the Culture of Healing in Late Imperial China
(2014-06-06)This dissertation examines the intersection between the culture of knowledge and socio-economic conditions of late Ming and Qing China (1550-1800) through the lens of materia medica. I argue that medicine in China during ... -
Assembly and Regulation of the Inflammasome Governed by a Unified Polymerization Mechanism
(2016-05-13)The innate immune system employs a diverse set of pattern recognition receptors to detect intrinsic and extrinsic danger signals for host protection. Inflammasomes represent an important class of receptors that elicit ... -
Assembly and Regulation of the Lipopolysaccharide Transporter
(2013-02-20)The hallmark of Gram-negative bacteria is the presence of an outer membrane (OM) surrounding the cytoplasmic membrane (here called the inner membrane [IM]) and the cell wall. The OM is a unique asymmetric bilayer with an ... -
Assembly of Centromeric Nucleosomes in Budding Yeast
(2020-11-23)The nucleosomes at centromeres contain a specialized histone H3 variant (CENP-A in metazoans/Cse4 in budding yeast) that is essential for recruiting kinetochore proteins and ensuring proper segregation. The deposition of ... -
Assessing Experiences of Weight Stigma and Disordered Eating Among New England-based and Latinx Young People
(2021-11-16)Background: Experiencing weight stigma and discrimination has significant impacts on our long-term health. Understanding exposure over the life course, especially during childhood and adolescence, are crucial to unravel ... -
Assessing indoor exposures to particulate matter and radon
(2021-01-20)Indoor air pollutants are ranked in the top five environmental risks to public health. As the time spent indoors is large enough and increasing over time, we were interested in understanding sources, transport, physicochemical ... -
Assessing modularity of developmental enhancers in Drosophila melanogaster
(2014-10-22)Gene expression is critical for animal development as cells divide and differentiate into multiple cell types. Cell-type specific gene expression is controlled by enhancers, DNA sequences that can direct expression of a ... -
Assessing relationships between discrimination and health: emphasis on measurement and methodology
(2021-07-12)Research investigating relationships between discrimination and health has grown over the past two decades, establishing a body of evidence that documents the adverse health outcomes associated with inequitable systems. ... -
Assessing Sanctions Motivations via Real-Time Shipping Data
(2024-01-22)Contemporary sanctions literature is bogged by conflicting analysis of initiator goals and sanction efficacy in addition to numerous paradoxes and selection effect concerns. I believe there is greater potential for academic ... -
Assessing the Air Pollution Health and Climate Impacts of Transportation as the U.S. Shifts to Electric and Autonomous Vehicles
(2021-03-05)Vehicles remain a major climate and public health issue in the United States despite decades of regulation. In order to mitigate this burden, electric vehicles (EVs) are starting to be deployed in larger numbers, and there ... -
Assessing the Effectiveness of Scrubber Installation on Air Pollution Emissions Reductions Among Coal-Fired Power Plants: Application of Statistical Methods for Causal Inference
(2015-04-08)The 1990 amendment to the Clean Air Act implemented a cap-and-trade system that required electricity-generating power plants to dramatically reduce Sulfur Dioxide (SO2) and Nitrogen Oxide (NOx) emissions. Plants impacted ... -
Assessing the Implementation of U.S. Programs and Policies for the Prevention of Food Insecurity and Obesity in School Settings
(2023-06-01)Five million children in the U.S. live in households experiencing food insecurity and may face numerous structural and environmental barriers to health that elevate the risks of physical, developmental and emotional harm, ... -
Assessing the Sense of Self
(2020-11-23)Can there be a science of the sense of self? If science is the objective study of general principles, beyond the particularities of individuals, can the subjective sense of self ever be described, measured, and modeled in ... -
Assessing the Skill of Six CMIP6 Climate Models in Predicting Arctic Sea Ice to Narrow the Uncertainty in Projections of the September Ice-Free Arctic
(2022-03-08)Arctic sea ice is an important indicator and regulator of the state of the global climate. As global temperatures rise due to climate change, Arctic sea ice is undergoing unprecedented rapid melting, bringing vast physical ... -
Assessing Value and Optimizing Decision-Making in Post-Acute Care Across Diverse Populations
(2024-01-29)My dissertation investigates the enhancement of value in post-acute care (PAC) within the U.S. healthcare system, focusing on the largest source of geographic variation in Medicare costs. It combines individual preferences, ... -
Asset Managers and Financial Instability: Evidence of Run Behavior and Run Incentives in Corporate Bond Funds
(2015-06-26)Asset managers may be a source of systemic risk due to their risk-taking strategies and vulnerability to dramatic outflows. Investor withdrawals trigger asset sales and redemption costs that only impact remaining investors ... -
Assistive Exoskeleton for Injury Prevention During Downhill Walking
(2015-04-08)This thesis presents a device designed to reduce muscular effort during downhill walking. The designed solution is a soft wearable exoskeleton consisting of an air spring, a wearable soft fabric interface that attaches the ... -
Associations Among Exposure to Adversity, Stress Reactivity, Cognitive Self-Regulatory Functioning, and Depression Symptoms in Middle School Youths
(2018-08-17)Identifying and understanding the pathways of risk and maintenance for child and adolescent (youth) depression has been a significant focus in the field of clinical psychological science. Although extensive research has ... -
Astrocytes promote pediatric glioma progression and enhance ex vivo tumor modeling
(2022-09-08)Astrocytes constitute approximately 10-20% of all cells in the human brain and are generally tasked with maintaining tissue homeostasis. These cells support neuronal metabolism and ion transport, regulate the extracellular ... -
Asymmetric Catalysis of Ionic 1,2-Rearrangements
(2022-03-17)In Chapter 1, we report the development and study of an aryl-iodide-catalyzed Wagner–Meerwein rearrangement reaction. This process converts styrenes bearing cumyl, t-butyl, and i-propyl substitution into enantioenriched ...