Browsing FAS Theses and Dissertations by Title
Now showing items 479-498 of 6136
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Biochemical Studies of TRP Channel Activation and Modulation
(2016-10-19)TRP channels are the cellular sensors behind many elements of somatosensation, including temperature sensing and the perception of pain. In fact, two channels, TRPV1 and TRPA1, expressed in pain-sensing nociceptor neurons, ... -
The Biochemistry and Physiology of Peptidases
(2013-03-14)Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which ... -
Bioelectronics for Cellular Electrophysiology during Tissue Development
(2023-11-21)Gaining insights from high spatiotemporal resolution electrophysiology studies of developmental biosystems, such as developing brains or organoids, is pivotal. These studies play a fundamental role in understanding the ... -
Bioinformatic and Mechanistic Studies of Radical Enzymes in Human and Animal Gut Microbiomes
(2023-06-01)The gut microbiomes of animals and humans consist of the trillions of microorganisms co-existing within and outside the host. These niches represent some of the densest microbial communities on Earth, with the microbes ... -
Bioinformatic and molecular study of the regulation of SIRT3 expression
(2015-01-29)Calorie restriction (CR) is a dietary intervention that extends lifespan, delays the onset of age-related diseases, and induces a wide-ranging metabolic adaptation in multiple model organisms. One of its primary effectors ... -
Bioinspired electronics for minimally invasive brain probes and regenerative medicine
(2020-08-11)Advancing the capabilities of neurotechnology could help answer fundamental questions in neuroscience, such as memory encoding, consolidation, storage and retrieval, as well as lead to improved treatments of neurological ... -
Bioinspired Photonic Crystals: Self-Assembly, Surface Functionalization, and Sensing in Inverse Opals
(2023-12-13)From moth wings to lotus leaves, the natural world has many examples of combining self-assembled nanostructured surfaces and surface energy control to manipulate the interactions between liquids and surfaces.1,2 These ... -
Bioinspired Slippery Solutions for Marine Fouling Prevention
(2024-03-12)Recent decades have seen an uptake in the development of non-toxic fouling prevention treatments, especially for marine applications. This trend is driven by technological innovation as a deeper understanding of material ... -
Bioinspired, Dynamic, Structured Surfaces for Biofilm Prevention
(2012-11-14)Bacteria primarily exist in robust, surface-associated communities known as biofilms, ubiquitous in both natural and anthropogenic environments. Mature biofilms resist a wide range of biocidal treatments and pose persistent ... -
Biological Characterization of Differential Function and Activation Between Closely-Related TGFβ Family Ligands
(2021-07-12)Growth differentiation factor 11 (GDF11) and GDF8 (also known as myostatin/MSTN) are closely-related members of the transforming growth factor β (TGFβ) family of extracellular ligands. Due to the high sequence identity of ... -
Biological Insights From Population Differentiation
(2017-05-13)Population genetics studies the genetic variation within and between populations to gain understanding of human history and insight into underlying biological processes. My dissertation introduces three distinct methods: ... -
Biologically-Aware Algorithms for Connectomics
(2021-05-13)With billions of neurons and trillions of synapses in humans, the inner workings of the brain remain one of the great open mysteries of the universe. A complete understanding of the brains of even tiny organisms such as ... -
Biologically-Inspired Deep Predictive Learning for Episodic Memory Event Segmentation
(2022-05-23)Computational modeling for event segmentation in the literature has been directed towards detailing individual regions of the brain, mainly the hippocampus, prefrontal cortex and substantia nigra and the role they play in ... -
Biology at single-molecule and single-cell level: chromosome organization, gene expression and beyond
(2014-06-06)Single molecules and single cells are the fundamental building blocks in biology. Facilitated by the advancement of technology, quantitative single-molecule and single-cell measurements provide a unique perspective toward ... -
Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase
(2015-09-22)Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ... -
Biomaterial scaffold-based vaccines sustain robust immune responses through the lymph nodes
(2022-05-05)Emergent vaccine therapies aim to engineer the multi-scale interactions that naturally occur within lymph nodes (LNs), from cellular behavior to tissue dynamics. Therapeutic cancer vaccines have demonstrated safety and ... -
Biomaterials-Inspired Advances to CAR T Cell Therapy: Strategies to Recognize Tumors and Enhance T Cell Activity
(2021-11-16)Chimeric antigen receptor (CAR) T cell therapy, among other adoptive cell transfer approaches, has emerged as a promising strategy to introduce tumor-specific T cells into patients. CAR T cell therapy, in particular targeting ... -
Biomechanical Therapy: A Soft Robotic Drug Delivery Device
(2017-07-14)This work establishes proof of concept and major progress towards a novel soft implantable drug delivery device, capable of controlled biological and mechanical therapy. -
The Biomechanics and Evolution of High-Speed Throwing
(2012-10-31)Throwing with power and accuracy is a uniquely human behavior and a potentially important mode of early hunting. Chimpanzees, our closest living relatives, do occasionally throw, although with much less velocity. At some ... -
The biomechanics and evolution of impact resistance in human walking and running
(2016-01-12)How do humans generate and resist repetitive impact forces beneath the heel during walking and heel strike running? Due to the evolution of long day ranges and larger body sizes in the hominin lineage modern human ...