Browsing FAS Theses and Dissertations by Title
Now showing items 654-673 of 6136
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Cellular Targets of Propranolol in Infantile Hemangioma
(2014-02-25)Infantile hemangioma (IH) is a vascular neoplasm that affects 4-10 percent of infants. Propranolol, a non-selective beta-adrenergic receptor (AR) antagonist, was serendipitously discovered to accelerate regression of IH ... -
Central Control Circuit for Context-Dependent Micturition
(2016-12-13)Precise control of urine release (micturition) serves an essential physiological function, as well as a critical role in social communication in many animals. Here we show a combined effect of olfaction and social hierarchy ... -
Central role for Sonic hedgehog-triggered pericytes in hindbrain choroid plexus development
(2014-02-25)The choroid plexus is an organ within each brain ventricle comprised of elaborate folds of epithelium (CPe) and vasculature. It performs numerous functions essential for brain development and health, including secretion ... -
Centralized Management in Democratic Governance—Essays on Organizing a System of Executive Branch Bureaucracies
(2023-06-01)This dissertation contributes to our understanding of how non-elected government actors can manage and lead a system of executive branch government bureaucracies to better advance both administrative capacity and democratic ... -
Cerebral Data Structures: Integrating Context into Data Structure Design and Implementation
(2022-05-11)The speed at which computer programs execute operations is fundamental to the way we build applications, with faster performance lowering operational costs and creating better user experiences. In addition, faster performance ... -
Certainty and War
(2016-05-11)Does greater certainty about an adversary’s attributes cause peace? What states believe they can secure through force dictates the diplomatic settlements they will accept. In prevailing accounts which preclude assessment ... -
cGAS-like receptors in animal innate immunity
(2023-05-04)The molecular detection of pathogen infection and subsequent initiation of an immune response is an essential function of cellular life. Animals encode innate immune proteins known as PRRs (pattern-recognition receptors) ... -
Challenging Cooperation: Inequality, Global Commons, Future Generations
(2016-04-25)Cooperation is abundant in the world around us, spanning all levels of biological and social organisation. Yet the existence and maintenance of cooperation is puzzling from an evolutionary perspective because the costs ... -
Challenging the Dominant Currency? Exchange Rate Pass-Through in China's Importing Trades
(2017-10-13)I examine China’s import trade, in particular how China’s import prices fluctuate with movements in the exchange rate of Chinese currency RMB (yuan) against both international currencies such as the Euro and the US dollars ... -
Changing Climates: Deserts, Desiccation, and the Rise of Climate Engineering, 1870-1950
(2014-10-22)This dissertation examines the impact of the nineteenth-century discussions about climate change and desiccation on large engineering projects in desert regions between 1870 and 1950. It demonstrates that the debate over ... -
Channel Length Scaling in Microwave Graphene Field Effect Transistors
(2018-05-12)In order to operate at microwave frequencies and higher, the channel length of a field effect transistor must be made very short ($\sim25$nm at 1THz) to minimize input capacitance and the drift time of carriers through the ... -
Character before the Novel: Representing Moral Identity in the Age of Shakespeare
(2013-02-20)This dissertation argues that the modern concept of literary character was an unintended consequence of Renaissance moral poetics. The evolution of "character" as a term of literary analysis, from the rediscovery of ... -
Character displacement and community assembly in Anolis lizards
(2013-10-08)At broad scales, community ecologists study how biogeographic factors like environmental dissimilarity and geographic distance influence community assembly and composition. At small scales, community ecologists study how ... -
Characterization and Biocatalytic Potential of an Enzymatic Friedel–Crafts Alkylation from Cylindrocyclophane Biosynthesis
(2022-06-06)The cyanobacterial enzyme CylK assembles the cylindrocylophane natural products by performing two sequential Friedel–Crafts alkylation reactions, forming new alkyl–aryl carbon–carbon bonds between resorcinol nucleophiles ... -
Characterization and Disruption of Cis Regulatory Elements in Cancer
(2016-05-11)Enhancers are cis regulatory elements that play key roles in the control of cell-type specific gene expression programs. In cancer, enhancer deregulation plays a key role in maintaining gene regulatory programs that underlie ... -
Characterization and functional modulation of the cancer stem cell state in colorectal cancer
(2021-05-14)Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the United States and is characterized by a high degree of intratumor heterogeneity, which likely contributes to the difficulty in ... -
Characterization and Mitigation of Bias in Parametric Mapping of Reward-Induced Dopamine Release using Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging
(2020-09-25)The dopamine system plays an essential role in learning associated with reward expectation and receipt. [11C]Raclopride positron emission tomography (PET) can be used to observe dopamine D2/D3 receptor binding and its ... -
Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation
(2016-04-04)The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ... -
Characterization of host and bacterial factors critical for Shigella flexneri pathogenesis
(2014-10-21)Shigella species are Gram-negative bacterial pathogens acquired by fecal-oral spread. A common cause of bacillary dysentery worldwide, particularly in developing countries, Shigella invade colonic mucosal cells and employ ... -
Characterization of human TRPA1 and TRPV1 channels in response to naturally occurring defensive compounds
(2013-10-08)The transient receptor potential channels, ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), are non-selective cation-permeable channels that have retained their function as chemical sensors since their first appearance in metazoan ...