Browsing FAS Theses and Dissertations by Title
Now showing items 671-690 of 6136
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Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation
(2016-04-04)The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ... -
Characterization of host and bacterial factors critical for Shigella flexneri pathogenesis
(2014-10-21)Shigella species are Gram-negative bacterial pathogens acquired by fecal-oral spread. A common cause of bacillary dysentery worldwide, particularly in developing countries, Shigella invade colonic mucosal cells and employ ... -
Characterization of human TRPA1 and TRPV1 channels in response to naturally occurring defensive compounds
(2013-10-08)The transient receptor potential channels, ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), are non-selective cation-permeable channels that have retained their function as chemical sensors since their first appearance in metazoan ... -
Characterization of impaired CD8+ T cell responses to Chlamydia trachomatis
(2013-10-15)Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Irregular screening to identify infected individuals and a lack of sterilizing immunity to C. trachomatis has ... -
Characterization of lung tumor-propagating cells reveals a role for CD24 and Yap/Taz in lung cancer progression and metastasis
(2014-06-06)Lung cancer is the leading cause of cancer deaths worldwide. A large part of this high mortality rate is due to the onset of metastatic disease prior to diagnosis. Advances in treatment for metastatic disease may be achieved ... -
Characterization of Malaria Sexual Stage Development in the Human Host
(2013-09-26)Due to an increase in malaria control programs in the last decade, the world has witnessed dramatic reductions in the number of infections and deaths caused by the malaria parasite. With malaria eradication on the global ... -
Characterization of nucleosome occupancy in mammalian cells
(2014-10-21)Chromatin is a complex of genomic DNA, RNA, and associated proteins. Many of the processes that occur on chromatin regulate the accessibility of the genetic material of a cell. The nucleosome is the basic subunit of ... -
Characterization of Protein-Metabolite and Protein-Substrate Interactions of Disease Genes
(2014-06-06)Discovery of protein-metabolite and protein-substrate interactions that can specifically regulate genes involved in human biology is an important pursuit, as the study of such interactions can expand our understanding of ... -
Characterization of the Antibacterial Activity of the Type VI Secretion System
(2014-02-25)This dissertation summarizes advances made toward understanding of the composition, structure, mechanism, and regulation of the bacterial type VI secretion system (T6SS). The T6SS is a widely conserved bacterial nanomachine ... -
Characterization of the functions and therapeutic potential of deubiquitinating enzymes in oncology
(2021-09-02)DUBs are dysregulated in cancer and other diseases, but there is much that is unknown about the specific substrates and pathways that individual DUBs regulate and their clinical utility remains incompletely explored. In ... -
Characterization of the In Vivo Function of Neuropilin1 during Development
(2013-02-20)Neuropilin1 (Npn1) is a transmembrane receptor that is critical for development of both the nervous and vascular systems. It is a ligand for both the chemorepulsive Semaphorin3s and for vascular endothelial growth factor ... -
Characterization of the Mamu-A*01-Restricted CD8-Positive T Lymphocyte Immunodominance Hierarchy in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
(2012-10-29)\(CD8^+\) cytotoxic T lymphocytes (CTLs) play a critical role in controlling human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. The CTL responses that are thought to be the most protective ... -
Characterization of the Responses to Electrical and Optical Stimulation of the Cochlear Nucleus in a Mouse Model of the Auditory Brainstem Implant.
(2022-05-12)The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides a sense of hearing by stimulating the cochlear nucleus (CN), the first auditory nucleus in the brainstem. Currently, the performance of most ... -
Characterization of the Trypanosoma cruzi flagellum in replicative stages
(2023-03-21)Trypanosoma cruzi is a kinetoplastid parasite which causes Chagas disease in humans. Chagas disease is a neglected tropical disease, which can lead to chronic cardiac and gastrointestinal disorders. Few treatments are ... -
Characterization of transcription factor function during human gametogenesis via directed differentiation
(2022-06-06)It is estimated that one in ten people in the US struggle with infertility. Access to human germline cell types for study is limited, and little is known about the underlying genetic regulation of human gametogenesis. In ... -
Characterizing anaerobic taurine metabolism by the human gut bacterium and opportunistic pathogen Bilophila wadsworthia
(2022-06-06)The human gut microbiome performs diverse chemical transformations that impact host health, nutrition, and disease. While the field has discovered numerous correlations between gut microbiome composition, metabolite ... -
Characterizing chemosensory responses in C. elegans with multi-neuronal imaging
(2021-07-12)How do animals use their sensory neurons to perceive their chemical environment? How does sensory information get transformed by downstream circuits? And ultimately, how do animals generate behavior in response to chemical ... -
Characterizing Distant Worlds: Atmospheric Reconnaissance of Giant Planets with Hubble
(2021-05-10)With over 4,000 exoplanet discoveries to date, we have caught a glimpse of the broad diversity of planets that span a range of masses, compositions, and orbital configurations. The next chapter in exoplanet exploration ... -
Characterizing Functional Genetic Diversity in Mycobacterium tuberculosis
(2023-04-26)The bacterium Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is the deadliest infectious disease in the world. Mtb is genetically conserved compared to most other human pathogens, so ... -
Characterizing immune crosstalk in the precancerous tissue
(2023-11-21)Extensive work within the field of cancer immunology has successfully characterized the tumor immune microenvironment and its impact on patient responses to therapy. However, there has been substantially less work dedicated ...