Browsing FAS Theses and Dissertations by Title
Now showing items 687-706 of 6097
-
Characterizing Regulatory Elements and Non-Coding Variants in the Human Genome
(2023-05-02)Regulatory elements and the non-coding variants within them govern the spatiotemporal expression of genes as part of coordinated sets of networks, mediated by the combinatorial binding of transcription factors. The mechanisms ... -
Characterizing the Evolution of Contact Area in Frictional Interfaces
(2019-05-15)Seemingly static interfaces between two solids are in fact dynamic. These multicontact interfaces (MCIs) exert enormous stresses on tiny contact areas, causing time-dependent deformation. Though these phenomena are ubiquitous ... -
CHARACTERIZING THE HYPOTHETICAL: BLACK U.S. PRESIDENTS IN LITERARY POPULAR CULTURE DURING THE LATE-JIM CROW ERA
(2022-11-23)In 1961, Attorney General Robert Kennedy famously predicted that a Negro could become President of the United States within thirty to forty years. He was inspired by the Presidential election of his brother, John F. Kennedy, ... -
Characterizing the Machine Learning Capabilities of General-Purpose CPUs
(2017-10-13)Machine learning is a ever-growing field, with many people interested in trying it out on their own. While there is specialized hardware to run machine learning algorithms, it costs a considerable amount to invest into ... -
Characterizing the transcriptional and chromatin landscapes of cancer metastasis
(2023-05-12)Cancer cells must overcome numerous challenges in order to establish distant metastatic lesions. Thus, distinct molecular programs are required to provide cancer cells with the ability to adapt and develop overt metastases. ... -
Charged Amalgamations of Mass-Produced Housing, Architecture, and Great War Technologies, 1916 to 1926
(2021-03-05)The concept of mass-produced housing occupies a prominent position in the modern architectural discipline. For many decades, architects have persistently attempted to devise residential designs that can be quickly and ... -
Charting Evolutionary Paths of Least Resistance
(2017-04-12)The efficacy of therapeutics such as antibiotics and cancer immunotherapy is double-edged: as they eradicate agents of disease, they simultaneously select for resistant populations, eventually causing their own obsolescence. ... -
Chemical and Cellular Defenses against Foreign Pathogens
(2012-09-07)Bacterial and viral infections affect billions of people each year. While bacterial infections are treated by the use of antibiotics, viral infections are eradicated by the immune system. This thesis comprises two parts. ... -
Chemical and Physical Determinants of Cell Migration
(2014-06-20)The phenomenon of directed cell motion in response to external directional cues has drawn significant interest for more than a century, with the first recorded observations of bacterial chemotaxis at the end of the 19th ... -
A Chemical Approach Identifies CDK4 as a Regulatory Component of Glucose Metabolism
(2014-06-06)Mammals have to adapt quickly to the changes of nutrition availability. The liver is the central organ that coordinates the responses to food deprivation upon fasting and nutrient overload during feeding. In liver, hormonal ... -
Chemical Approaches to the Surface Engineering of Paper and Cellulose-Based Materials for Microfluidics, Electronics and Low-Cost Diagnostics
(2016-01-27)Paper (and other cellulose-based materials such as cotton thread and fabrics) are underexploited as materials for the construction of “high-tech” and “lab-on-a-chip” devices. One major drawback of paper is its tendency to ... -
Chemical Genetics of Hematopoietic Stem Cell Transplantation
(2012-09-18)Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. ... -
Chemical Neurobiology of the Histone Lysine Demethylase KDM1A
(2016-05-18)Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. The enzymes responsible for epigenetic regulation may thus be important therapeutic targets for ... -
Chemical Probes and the Exploration of Bromodomains in Cancer Biology
(2014-06-06)The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate ... -
Chemical proteomics and biochemical investigation of chemical degraders that engage cereblon
(2022-11-23)Chemical degraders are a unique class of molecules that re-wire ubiquitination for targeted protein degradation. These compounds typically function by inducing physical proximity between an E3 ligase and the target protein ... -
Chemical Vapor Deposition of Cobalt-based Thin Films for Microelectronics
(2014-02-25)In microelectronics, the device size continues to shrink to improve the performance and functionality, which sets technical challenges for the integrated circuit (IC) fabrication. Novel materials and processing techniques ... -
Chemical Vapor Deposition of Thin Film Materials for Copper Interconnects in Microelectronics
(2012-07-24)The packing density of microelectronic devices has increased exponentially over the past four decades. Continuous enhancements in device performance and functionality have been achieved by the introduction of new materials ... -
A Chemical-Genetic Study of EphB Receptor Tyrosine Kinase Signaling in the Developing Nervous System
(2012-11-06)EphB receptor tyrosine kinases regulate cell-cell contacts throughout nervous system development, mediating processes as diverse as axon guidance, topographic mapping, neuronal migration and synapse formation. EphBs bind ... -
Chemoproteomic target-class drug discovery against the deubiquitinating enzymes
(2022-03-17)Modern small molecule drug discovery is dominated, and subsequently limited by a paradigm of reversible non-covalent inhibitors. The deubiquitinating enzymes (DUBs) is a class of ~100 proteases that regulate normal and ... -
Childhood Anxiety Disorders: Developmental Risk Factors and Predictors of Treatment Response
(2016-07-26)Cognitive Behavioral Therapy (CBT) is the evidence-based treatment of choice for childhood anxiety disorders. Its blend of cognitive and behavioral coping strategies for anxiety management has more empirical support than ...