Browsing FAS Theses and Dissertations by Title
Now showing items 757-776 of 6136
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Climate Change and Health: Implications for Cardiovascular Diseases and Inherently Hot Regions
(2022-06-06)The warming of our planet is unevenly distributed. In inherently hot and hyper-arid countries like Kuwait, temperatures are already soaring to unprecedented record-high levels and not a lot is known about what climate ... -
Climate Change and Inequality in the U.S.: Sociological Analyses of Big Data
(2021-05-11)Anthropogenic climate change is altering the severity, frequency, and spatial patterning of extreme weather in the United States. Sociologists have argued that the resulting disasters exacerbate social inequality, yet ... -
Climate Model Bias Correction: Implementation and Applications
(2023-09-05)This dissertation focuses on the methodology and usage of bias correction methods to understand and address problems stemming from climate model mean state biases over the course of three research chapters. Chapter 2 details ... -
A Climate-friendly Energy Future: Prospects for Wind
(2014-06-06)The objective of this thesis is to evaluate the potential for wind as an alternative energy source to replace fossil fuels and reduce global CO2 emissions. From 1995 to 2007, fossil fuels as the major energy source accounted ... -
Climates on the Move: Climatology and the Problem of Economic and Environmental Stability in the Career of C.W. Thornthwaite, 1933-1963
(2014-06-06)This dissertation examines the role of climate science in ensuring environmental stability. It traces the career of the climatologist Charles Warren Thornthwaite, beginning with his work as a population geographer for the ... -
Clinical trial data science to advance precision oncology
(2022-04-04)Clinical trials are the most expensive and highest-stakes experiments in biomedicine, and their results determine which therapies are ultimately used to treat patients. While a typical pivotal trial costs millions of dollars ... -
Clogging Mechanisms in Converging Microchannels
(2016-01-29)Many technological and biomedical applications ranging from water filtration and oil extraction to arteriosclerosis and vein thrombosis rely upon the transport of solids in liquids. Particulate matter suspended in liquid ... -
Clonal Analysis of Mucosal SIV-Specific CD8+ T Cell Responses
(2013-02-26)CD8+ T cells responses are critical in the immune defense against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. A major challenge for vaccine development is that HIV/SIV can rapidly ... -
Clonal analysis of native and malignant hematopoiesis using color barcoding in zebrafish
(2018-01-19)Hematopoietic stem cells (HSCs) emerge from the dorsal aorta during embryogenesis and sustain lifelong blood production. Over time, HSC clones accumulate mutations that may cause clonal expansion at the expense of normal ... -
Clp-Mediated Regulation of the Mycobacterial Cell Cycle
(2017-04-12)Tuberculosis is currently the most deadly infectious disease worldwide. Given the high rates of treatment failure, new antibiotics are desperately needed. Antibacterial drugs typically target DNA replication, cell growth, ... -
Cluster Algebras and Mirror Symmetry for Homogeneous Spaces
(2023-05-09)Homogeneous spaces lie at the intersection of various fields of study, and as a result possess an incredibly rich structure. This thesis focuses in particular on the interactions between cluster algebras and mirror symmetry ... -
Cluster-based outcome-dependent sampling: inference and frameworks for efficient sampling designs
(2021-07-12)Efficient sampling designs are valuable in public health research when finite resources necessitate decisions regarding which individuals to sample for detailed data collection. In observational studies, when the outcome ... -
Clustering of Single-Cell and Text Data
(2023-07-31)In recent years, we have witnessed the rapid growth of the data volume and a significant fraction of the unlabeled data. We study the problems of subject clustering in bioinformatics and document clustering in Natural ... -
Clustering via Deep Dictionary Learning
(2021-06-04)Clustering, the process of discovering hidden groups in data, is a fundamentally important problem in statistical data analysis with applications ranging from image segmentation to sequence analysis to anomaly detection. ... -
ClustHP: An Unsupervised Learning Pipeline for the Homoplasy Scoring of Single Nucleotide Variants
(2023-04-19)Homoplastic variants arise multiple times independently in distinct lineages of a population. Homoplasy is a strong signal of positive selection and even adaptive evolution. Identifying the most homoplastic variants in a ... -
CMOS Interface for Mammalian Electrogenic Cell Interrogation
(2016-10-19)Classical tools to record and stimulate electrogenic cells, mainly cardiac cells and neurons, are intracellular patch clamp micropipettes and extracellular microelectrode arrays (MEAs). The former has high precision while ... -
CNT-based Electrochemical Filter for Water Treatment: Mechanisms and Applications
(2015-05-07)Water treatment is a critical global challenge requires innovated effective solution. Conventional treatment methods includes membrane filtration, adsorption and electrochemical oxidation of organics. This dissertation ... -
Co-opting Intracellular Proteins for Cell-Specific Gene Manipulation
(2015-01-22)Studies of complex multicellular organisms would benefit from the ability to selectively manipulate the activities of any cell type of interest. Our ability to achieve this is currently limited by technology and available ... -
Co-Producing Futures: The Making of “Hollywood’s” Apocalyptic Aesthetic in South Africa
(2021-09-08)This dissertation explores the presence of “global Hollywood” in South Africa and the social worlds of the Western Cape’s film-service economy; a significant segment of South Africa’s film industry that facilitates the ... -
Co-targeting epigenetic and oncogenic enzymes in HER2+ breast cancer
(2022-01-19)Breast cancer is the most prevalent cancer worldwide with over 2 million women diagnosed every year, and caused 685,000 deaths globally in 2020. 15-25% of breast cancer patients overexpress the receptor tyrosine kinase ...